慢性焦虑抑郁与血糖血脂及血浆纤维蛋白原水平的相关性

摘要

Objective For the purpose to Understand the mechanisms of the interaction between the spirit and the body, in this article, we tried to explore the correlation between the scores of chronic anxiety and depression disorders of the patients and the concentrations of the fasting plasma glucose, blood lipids and plasma ifbrinogen of the same patients. Methods According to the diagnostic criteria of anxiety, depression in DMS-Ⅳ, all the patients who were admitted in our hospital neurological department from December 2012 to April 2013 were scored in severity about chronic anxiety and depression disorders for the past 20 ~ 30 years or more by a same experienced psychiatric clinician. At the same time, all the patients’ fasting plasma glucose, blood lipids and plasma ifbrinogen concentrations were checked. Then, the relationship between the scores of chronic anxiety and depression disorders and the concentrations of the fasting plasma glucose, blood lipids and plasma ifbrinogen were analyzed. Results Anxiety disorders scores have on signiifcant correlation with the concentrations of fasting plasma glucose and blood lipids (P>0.05), but it has a signiifcant Reversed correlation with plasma ifbrinogen concentrations (P<0.01);Depression disorders scores have on correlation with fasting plasma glucose, blood lipids and plasma ifbrinogen concentrations(P > 0.05);Compared with the group without anxiety disorders, the group with anxiety disorders has lower fasting plasma glucose concentration, but the Statistical significance is not obvious (P = 0.094). Conclusion Chronic anxiety disorders maybe play a role of decreasing the plasma ifbrinogen concentration of the Patients, therefore it may be a protective factor for the thrombotic diseases such as cerebral infarction, coronary heart disease et al.%目的：探讨慢性焦虑、抑郁障碍与血糖、血脂及血浆纤维蛋白原（Fg）水平的相互关系，进而为了解精神因素与躯体疾病之间的精神生物学机制提供线索。方法按照DMS-Ⅳ标准，对本院神经科于2012年12月至2013年4月间新入院的患者，由同一位有经验的精神科临床医师对他们进行入院前20～30年或更长时期以来的精神状态包括焦虑和抑郁两个方面进行严重程度评分，同时采集患者入院当日或次日血样，化验检测其空腹血糖、血脂及血浆Fg水平，然后进行统计分析，了解患者慢性焦虑、抑郁评分与其当前血糖、血脂及血浆Fg水平之间的关系。结果统计分析显示，焦虑障碍评分与血糖、血脂各指标之间无显著相关性（P＞0.05），与血浆Fg水平之间呈显著负相关（P＜0.01）；抑郁障碍评分与血糖、血脂各指标及血浆Fg水平之间均未显示有显著相关性（P＞0.05）。有焦虑组与无焦虑组做比较，有焦虑组血浆Fg水平明显低于无焦虑组（P＜0.01）。有焦虑组血糖水平低于无焦虑组，但无显著差异（P＝0.094）。结论慢性焦虑有降低血浆Fg水平的作用，从而对血栓形成性疾病如脑梗死、冠心病等可能有保护作用。