脑钠肽与内皮素-1对心力衰竭患者心血管事件的预测价值

摘要

ObjectiveTo observe the effect of brain natriuretic peptide (BNP) and endothelin-1 (ET-1) levels in the prognosis of heart failure patients, and study its relationship with cardiovascular disease.Method 183 cases of heart failure patients were admitted from January 2011 to December 2014 in our hospital as research group, while 180 cases of the healthy people were collected as control group during the same period. The BNP and ET-1 levels of the two groups were compared, and the changes of BNP and ET-1 levels of different cardiac function level and subtypes of research group were observed.ResultThe BNP and ET-1 levels of patients in research group were higher than control group (P<0.05), the higher the heart function classiifcation, the higher the BNP and ET-1 levels. BNP and ET-1 levels in patients with atrial ifbrillation and pulmonary hypertension were much higher than those in patients with no atrial fibrillation and pulmonary hypertension (P<0.05). After 6 months follow-up, BNP and ET-1 levels in patients with cardiovascular events were signiifcantly higher than those in patients without cardiovascular events (P<0.05).Conclusion BNP and ET-1 levels have an important clinical significance in the prognosis of heart failure patients, which can predict the incidence of cardiovascular events in the patients.%目的：观察脑钠肽（BNP）与内皮素-1（ET-1）对心力衰竭患者预后的预测价值，并研究其与心血管疾病的关系。方法选取本院2011年1月至2014年12月收治的183例心力衰竭患者纳入研究组，并选取本院同期180例健康体检者纳入对照组，比较两组研究对象BNP与ET-1水平以及不同心功能分级和不同亚型患者体内BNP与ET-1水平的变化。结果研究组患者体内BNP与ET-1水平均高于对照组（P＜0.05），且心功能分级越高，BNP与ET-1水平越高。伴心房颤动与肺动脉高压患者BNP与ET-1水平远高于无心房颤动与无肺动脉高压患者（P＜0.05）。随访6个月，发生心血管事件患者BNP与ET-1水平均显著高于未发生心血管事件患者（P＜0.05）。结论 BNP与ET-1水平变化在心力衰竭患者预后分析中具有重要的临床意义，通过检测二者水平可在一定程度上预测心血管事件的发生。