Objective To investigate the efficacy and safety of Amiodarone and Propafenone in the treatment of children with preexcitation syndrome complicated with atrial fibrillation. Method 80 children with preexcitation syndrome complicated with atrial fibrillation treated in our hosipital from June 2014 to December 2015 were divided randomly into control group (n=40, treated with Propafenone) and observation group (n=40, treated with Amiodarone combined with Propafenone), the efficacy and adverse reaction of the two groups were observed. Result The effective rate of transfer of observation group (100%) was significantly higher than that of control group (85%) (P<0.05). The proportion of children who keep sinus rhythm after cardioversion in observation group were significantly higher than that of control group at 1 month, 3 months, 6 months and 12 months after hospital discharge were significantly higher than that of control group (P<0.01). The incidence rate of adverse reaction in the two groups had no significantly difference (P>0.05). Conclusion Cardioversion of amiodarone combined with propafenone on pre-excitation syndrome complicated with atrial fibrillation have high probability, patients' tolerance is good, it is safe and worthy of clinical application.%目的 探讨胺碘酮联合普罗帕酮对预激综合征合并心房颤动(房颤)患儿的有效性和安全性.方法 选取2014年6月至2015年12月本院收治的预激综合征合并房颤的患儿80例为研究对象,将其随机分为对照组(40例)和观察组(40例),对照组患儿常规静脉注射普罗帕酮,观察组患儿在对照组基础上加用胺碘酮,比较两组患儿的治疗效果和不良反应发生情况.结果 观察组患儿的转复有效率(100%)显著高于对照组(85%)(P<0.05);观察组患儿出院后1、3、6、12个月,复律后维持窦性心律的患儿比例均显著高于对照组(P<0.01);两组患儿不良反应发生率比较差异无显著性(P>0.05).结论 胺碘酮联合普罗帕酮对预激综合征合并房颤患儿的复律成功率高,患儿耐受性好,安全性有保障,值得临床推广.
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