HDAC6抑制剂的特性及应用

摘要

Histone deacetylases (HDACs) are a group of enzymes that regulate many biological processes associated with cell proliferation, metastasis and apoptosis. HDACs inhibitors can act on many processes of cellular biology, which may induce cell apoptosis, arrest cell cycle and suppress angiogenesis. Thus, they have been widely studied as a kind of anti-tumor agent. HDAC6 is being concerned as a promising therapeutic target for the treatment of Alzheimer's disease, glioblastoma multiforme and neuroprotection by more and more researchers. Several HDAC6 inhibitors have been researched until now, including ACY-1215, Tubacin, Tubastatin A, etc. We summarize the characteristics and the clinical application of some HDAC6 inhibitors in this review, and describe the application situation of this series of agents using in anti-cancer, neuroprotection and some other aspects.%组蛋白去乙酰化酶(histone deacetylases,HDACs)可调节与细胞生长、转移、凋亡相关的多种细胞途径.HDACs抑制剂可以影响多种细胞效应,诱导细胞凋亡,阻碍细胞循环,抑制血管生成,其作为一种抗肿瘤制剂被广泛研究.研究证实,HDAC6抑制剂在治疗阿尔茨海默病、脑胶质瘤及神经保护方面的作用也受到越来越多研究者的关注.目前研究的HDAC6抑制剂极为有限,主要包括ACY-1215、Tubacin、Tubastatin A等.本文对几种常见的HDAC6抑制剂的特性及其临床应用进行综述,阐述该类药物在抗肿瘤、神经保护及其他方面的应用现状.