目的:研制并观察猕猴应用立体网状镍钛记忆合金宫内节育器(SIUD)后的避孕效果,为避孕节育提供新的方法及实验数据.方法:SIUD支架为心形或倒梨形,用镍钛记忆合金丝编织成网格状支架,外包硅橡胶.成年雌性猕猴分为手术放置SIUD组(实验组)和假手术组(对照组)各9只,分别开腹进行子宫、卵巢外部测量,并观察放置SI-UD避孕效果.结果:猕猴用9只猕猴通过宫底穿刺用放置器顺利放置新型IUD,3个月时1只猕猴SIUD脱落后妊娠,其余8只未脱落均未妊娠;对照组9只均妊娠,两组差异有统计学意义(P=18.452,t=0.000).结论:猕猴子宫形状与人类相似度高,是研制新型SIUD的较好动物模型,猕猴用SIUD具有较好的避孕效果.%Objective:To develop a new stereoscopic intrauterine device (SIUD) for rhesus macaque,and to further provide the new contraception and experimental data for women birth control.Methods:The stent of rhesus macaque SIUD was heart -shaped or inverted pear-shaped,and was made from nickel-titanium memory alloy wires and was covered the layer of silicone rubber.The shape of SIUD was designed as three-dimensional network structure.Adult male rhesus macaques were selected and divided into SIUD experimental group (n=9) and control group (n=9).The entire male rhesus macaques were measured their uterus and ovary after laparotomy.And after laparotomy,the SIUD was inserted into the exposed uterus of rhesus macaques in SIUD experimental group.Results:,In experimental group,nine monkeys were successfully inserted a SIUD through uterine bottom puncture,and only one monkey's SIUD was expulsed and became pregnant (11.1 ％,1/9) after 3 months.9 monkeys in control all became pregnant (P=18.452,t=0.000).Conclusion:The shape of uterus of rhesus macaque is similar to that of human beings,so rhesus macaque is a good animal model for the development of new SIUD.Rhesus monkey SIUD has good contraceptive effects.
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