背景 视神经炎研究领域近年来发展较快,分支较多且复杂,了解视神经炎相关研究现状、研究热点,预测未来发展趋势,对于相关的科研和临床工作均十分重要. 目的 了解视神经炎研究文献的分布规律、学科知识结构并预测未来发展趋势. 方法 利用PubMed数据库为数据源,对2000年1月至2012年7月收录的视神经炎相关文献进行统计分析,采用多元统计方法对高频主题词共现矩阵进行转换、降维和聚类分析,绘制战略坐标图,并根据社会网络分析方法绘制可视化网络图谱.结果 共检出视神经炎相关文献2 191篇,发文量逐年增加.美国、英国、德国、荷兰和日本5个国家总发文量为1 615篇,占发文总数的73.71％.相关高频主题词共52个,成功建立视神经炎学科知识可视化图谱,直观展示了视神经炎的知识分布,并形成重点研究聚类,结果显示当前的热点主要集中在9个领域,其中免疫学研究已经较为成熟但处于边缘的地位,视神经炎病因及诊断、病理学研究、病理生理学研究和视神经脊髓炎(NMO)专题研究是目前研究的核心领域,药物治疗、非中枢性脱髓鞘性视神经炎研究、流行病学研究和遗传学研究相对薄弱,有较大的提升空间.结论 近年国际上对视神经炎的关注和发文量逐年增加,欧美国家的发文量占主导地位.国际视神经炎的研究热点主要集中在9个领域,可能为今后研究的发展方向.%Background The research field of optic neuritis has developed rapidly and become more complex in recent years.It is very important for the reseachers and clinicians to known its status and the future trend.Objective This survey was to learn the distribution pattern,subject domain knowledge and worldwide research tendency of optic neuritis based on literatures in PubMed database.Methods Literatures on optic neuritis published in January 2000 to July 2012 were identified in PubMed database.The analytic dimention of an article included journal,published year,author,country and language.After core Mesh terms had been characterised by bibliographic item co-occurrence mining system (BICOMS),the co-occurrence matrix was built.Cluster analysis and multiple diamensional analysis were finished by SPSS 17.0.Then visualized network was drawn using ucinet 6.0.Results Totally 2 191 literatures were included,the number of articles increased from 105 in 2000 to 282 in 2011.The United States,England,Germany,Netherlands and Japan together accounted for 73.71％ of articles.There were 52 high-frequency subjects and hot topics were clustered into 9 categories.The visualized domain knowledge map was successfully built.The immunologic research was fully developed.The topic on etiology and diagnostic research,pathologic research,physiologic research and neuromyelitis optica (NMO) research had become core domain,while the studies of medication therapy,non-central nervous system idiopathetic demyelinating optic neuritis,epidemiology and genetics were not developed well.Conclusions Global optic neuritis publications display a continuous growth in the new millennium.The Big 5 in scientific literature on optic neuritis are the United States,England,Germany,Netherlands and Japan.The international main research focus includes 9 fields,which may provide reference or scholars both in scientific research and clinical research.
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