重视干细胞治疗在视网膜疾病中的应用基础研究

摘要

视网膜独特的功能和解剖特点使其成为细胞治疗的合适靶点.目前,有多种干细胞被用于视网膜疾病的治疗研究,展现了其强大的应用潜能.然而,在干细胞治疗真正用于临床之前的阶段,仍有许多研究工作要做,如对于干细胞类型的选择、移植策略的制定、干细胞作用机制和生物安全性的确定,以及如何实现高效的干细胞的体外定向诱导分化,确定移植前干细胞的最佳个体发育阶段及有效实现干细胞在眼部组织中的结构和功能整合等方面,还需要进一步研究.%With the special organization structure and function,retina is thought to be a prime candidate for developing the cellular therapies.Many types of stem cells have been explored to use for the treatment of retinal diseases and exhibit significant potential for further clinical application.However,before these results are translated to a clinical setting,sufficient investigations are required,such as the selection of the type of stem cells,transplantation strategy,the mechanism of therapeutic effect and biological safety,and how to get high differentiation efficiency,clarify the best development phase before transplantation,and achieve effective functional and structural integration of stem cells in the retina,etc.