HBV感染慢性肝病患者血清GP73浓度对肝纤维化程度的诊断意义

摘要

目的 探讨血清GP73浓度与慢性HBV肝病患者肝纤维化程度之间的关系,以评估GP73在慢性HBV患者中的临床诊断价值.方法 选取慢性HBV感染者761名,分别进行FibroScan检测和血清GP73测试.结果 血清GP73浓度与肝硬度相关(r=0.601),ROC曲线下面积为0.76.GP73用于诊断显著肝纤维化(≥F2)的敏感性和特异性分别为62.81％和80.05％(cut off值:76.6ng/ml).结论 GP73可能是一种诊断慢性HBV感染者显著肝纤维化的新标志物.%Objective To investigate the relationship between serum concentration of GP73 and liver stiffness in chronic HBV liver disease,to evaluate clinical diagnostic value of GP73 in chronic HBV patients.Methods 761 patients with chronic HBV infection took liver stiffness measurement,and all patients had serum GP73 test.Results The concentration of serum GP73 and liver stiffness was related (r =0.601),area under the ROC curve was 0.76.GP73 for the diagnosis of significant fibrosis (≥ F2) the sensitivity and specificity were 62.81％ and 80.05％ (cut off:76.6 ng/ml).Conclusion GP73 may be a marker for diagnosis of chronic HBV infection significant liver fibrosis.