急性缺血性卒中患者血清Ox-LDL水平与疾病严重程度及预后的相关性

摘要

Objective To investigate the associations between oxidized low-density lipoprotein (Ox-LDL) with severity and outcome of acute ischemic stroke (AIS).Methods Serum of 141 AIS patients (AIS group) and 30 normal subjects (control group) were collected. Enzyme linked immunosorbent assay (ELISA) was used to test the level of serum Ox-LDL in two groups, the NIH Stroke Scale (NIHSS) were used to evaluate their neurological deficit on the first day of admission, and the Barthel Index (BI) were used to measure activities of daily living at sixth month.Results Ox-LDL level of AIS group was significantly higher than control group (P<0.05). Ox-LDL level of AIS group was correlated with NIHSS score (r=0.056,P<0.05), but not related to BI score (P<0.05).Conclusion Ox-LDL level of AIS patients is correlated with severity but not related to prognostic indicator.%目的：探讨急性缺血性卒中患者血清氧化型低密度脂蛋白（Ox-LDL）水平与卒中严重程度及预后的相关性。方法入选141例急性缺血性卒中患者（AIS组）和30例正常人（对照组）的血清，采用酶联免疫吸附法（ELISA）检测两组血清Ox-LDL水平，并在入院第1 d进行神经功能缺损程度评分（NIHSS），第6个月进行日常生活活动能力量表评分（BI）。比较AIS组与对照组Ox-LDL水平结果，并分析AIS组患者Ox-LDL水平与入院时NIHSS评分及6个月后BI评分的相关性。结果急性缺血性卒中组血清Ox-LDL水平明显高于对照组（P＜0.05），其Ox-LDL水平与第1天NIHSS评分存在显著相关性（r=0.056，P＜0.05），与第6个月BI评分无明显相关性（P＞0.05）。结论急性缺血性卒中患者血清Ox-LDL水平与临床严重程度有相关性，但与缺血性卒中预后指标的相关性不明显。