哮喘与冠心病风险相关性队列研究的Meta分析

摘要

目的：系统评价哮喘与冠心病发病风险的关系。方法计算机检索中国知网、万方数据库、PubMed及EMbase数据库中公开发表的有关哮喘与冠心病发病关系的队列研究文献，检索时限均为建库至2015年11月，采用NOS量表评价所纳入研究的质量，利用Meta分析方法计算纳入文献的合并HR值及95%CI值，并根据入选文献的研究性别、地域、人群来源差别，以及入选文献质量评分的高低进行亚组分析。结果最终纳入文献共6篇，随访队列总人数为510822例，累计冠心病患者18105例，Meta分析结果显示，与未患哮喘者相比，哮喘患者冠心病发病风险增加（HR=1.41，95%CI：1.36~1.45，P＜0.001）；亚组分析显示，哮喘人群中女性发生冠心病的风险高于男性，按地域、研究人群、质量评分不同进行的亚组分析均提示哮喘增加冠心病发病风险，结果均有统计学意义。结论哮喘与冠心病的发生有一定的关联，可能是冠心病的危险因素之一。%Objective To systematically review the association between asthma and risk of coronary heart disease (CHD).Methods A systematic literature search for asthma and the risk of coronary heart disease cohort studies were conducted in databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang, PubMed, EMbase until November 2015. Quality of all included studies were evaluated according to NOS tool. Meta-analysis was conducted to calculate pooled HR and corresponding 95% confidence intervals. We also conducted a number of sub-groups analysis stratified by gender, regions, populations and research quality.Results Six studies were included in the meta-analysis, with a total of 510, 822 subjects and 18, 105 CHD cases. The results showed that the risk of CHD in asthma patients was significant increased than subjects without asthma (HR=1.41, 95%CI: 1.36~1.45,P<0.001). Results of subgroup analysis suggested that the risk of CHD among asthma patients were higher in females than males. Results of subgroup analyses with respect of regions, populations and research quality showed statistical significance. Conclusion Asthma may be associated with increased risk of coronary heart disease.