Objective To discuss the relationship among serum growth differentiation factor-15 (GDF-15), creatine kinase MB (CK-MB), cardiac troponin I (cTnI) and myoglobin (Mb) in patients with acute myocardial infarction (AMI).Methods AMI patients (n=127, male 71, female 56, aged from 51 to 82 and average age=71.28 ±10.83) were chosen as observation group from Dec. 2013 to Dec. 2014. Meanwhile the healthy controls with physical examinations (n=104, male 62, female 42, aged from 50 to 84 and average age=70.02±11.76) were chosen as control group. The levels of serum GDF-15, CK-MB, cTnI and were detected in 2 groups.Results The level of serum GDF-15 was significantly higher in observation group than that in control group [(3.04±1.09) g/Lvs. (0.41± 0.13) g/L,P<0.01]. Compared with control group, the levels of cTnI, CK-MB and Mb increased [(0.31±0.11) g/L (3.82±1.53) g/L], [(16.53±5.09) g/Lvs. (45.07±13.16) g/L] and [(40.17±4.15) g/Lvs. (201.11±45.62) g/L] in observation group (allP<0.05). The results of Pearson correlation analysis showed that level of serum GDF-15 was positively correlated to cTnI, CK-MB and Mb (r=0.427,r=0.409,r=0.511, allP<0.05).Conclusion The levels of serum GDF-15, cTnI, CK-MB and Mb all increase in AMI patients, and GDF-15 is positively correlated to cTnI, CK-MB and Mb. GDF-15 may be a new diagnostic index for AMI.%目的：探讨急性心肌梗死（AMI）患者血清生长分化因子-15（GDF-15）与肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）、肌红蛋白（Mb）之间的关系。方法选取广东省台山市人民医院心内科2013年12月~2014年12月收治的AMI患者127例即观察组，其中男性71例，女性56例，年龄51~82岁，平均年龄（71.28±10.83）岁；同时选取在本院体检的健康人群104例作为对照组，其中男性62例，女性42例，年龄50~84岁，平均年龄（70.02±11.76）岁。检测两组血清转化生长因子15（GDF-15）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）、肌红蛋白（Mb）水平。结果观察组血清GDF-15水平明显高于对照组[（3.04±1.09）g/Lvs.（0.41±0.13）g/L]，差异有统计学意义（P＜0.01）。与对照组比较，观察组cTnI、CK-MB和Mb均升高，数值为[（0.31±0.11）g/Lvs.（3.82±1.53）g/L]、[（16.53±5.09）g/Lvs.（45.07±13.16）g/L]和[（40.17±4.15）g/Lvs.（201.11±45.62）g/L]，差异有统计学意义（P均＜0.05）。Pearson相关分析结果显示，血清GDF-15与cTnI、CK-MB、Mb呈正相关，相关系数分别为0.427、0.409、0.511（P均＜0.01）。结论急性心肌梗死患者GDF-15与cTnI、CK-MB和Mb均升高，且GDF-15越高cTnI、CK-MB和Mb也越高，GDF-15可能成为AMI诊断的新指标。
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