血尿酸、超敏C-反应蛋白与急性冠脉综合征危险分层的关系研究

摘要

目的 探讨血尿酸(SUA)、超敏C-反应蛋白(hs-CRP)与急性冠脉综合征(ACS)的危险分层相关性.方法 选取2012年6月~2014年3月收治并确诊ACS患者126例作为观察组,其中不稳定型心绞痛(UA)36例,非ST段抬高性心肌梗死(NSTEMI)42例,ST段抬高性心肌梗死(STEMI)48例.同时选取52例排除ACS的住院患者作为对照组,检测并比较两组患者SUA、hs-CRP水平.并分析SUA与hs-CRP在急性冠脉综合征患者中相关性.结果 STEMI组患者的SUA水平(735.19±146.98 mmol/L)和hs-CRP水平(17.06±7.87 mg/L)明显高于NSTEMI组、UA组及对照组,差异有统计学意义(P均<0.05).NSTEMI组、UA组的SUA水平[(579.13±60.12)mmol/L和(470.37±72.64)mmol/L]与对照组(349.09±80.74)mmol/L相比,明显升高(P<0.05).NSTEMI组hs-CRP水平(8.85±3.26)mg/L与对照组(2.30±1.27)mg/L相比,也有统计学差异(P<0.05),UA组hs-CRP水平(4.64±3.71)mg/L无统计学差异(P>0.05).SUA和hs-CRP水平有明显正相关(r=0.8766,P<0.01).结论 SUA及hs-CRP水平与ACS密切相关,检测SUA、hs-CRP水平对ACS的分层有临床意义.%Objective To explore the relationship between serum uric acid (SUA), high sensitive C-reactive protein (hs-CRP) and the different risk stratification of acute coronary syndrome (ACS).Methods 126 ACS patients in our Zhongshan People's Hospital from June 2012 to march 2014 were selected as observation group, including 36 patients with unstable angina pectoris (UA), 42 patients with non-ST-segment elevation myocardial infarction (NSTEMI), 48 patients with ST-segment elevation myocardial infarction (STEMI). At the same time, 52 non-ACS hospitalized patients were selected as the control group. The levels of SUA and hs-CRP were compared between the two groups, and the correlation between SUA and hs-CRP in patients with acute coronary syndromes was analyzed. Results The levels of SUA in patients with STEMI (735.19±146.98 mmol/L) and hs-CRP (17.06±7.87 mg/L) were significantly higher than those in NSTEMI group, UA group and control group (P<0.05). The levels of SUA in the NSTEMI group (579.13±60.12 mmol/L) and the UA group (470.37 ± 72.64 mmol/L) were significantly higher than those in the control group (349.09±80.74 mmol/L) (P<0.05). The levels of hs-CRP in the NSTEMI group (8.85 ±3.26 mg/L) were significantly higher than those in the control group (2.30±1.27 mg/L) (P<0.05), but were not different with the level of hs-CRP in the UA group (4.64±3.71 mg/L) (P>0.05). There was a significant positive correlation between SUA and hs-CRP levels (r=0.8766,P<0.01).Conclusion SUA and hs-CRP levels are closely related to ACS. Detection of SUA and hs-CRP levels are clinically significant for ACS stratification