新活素对老年失代偿性心力衰竭患者心功能的影响

摘要

目的 探讨新活素对老年失代偿性心力衰竭患者心功能影响.方法 选择中国人民解放军464医院干部病房科于2013年3月~2017年5月间住院的老年失代偿性心力衰竭患者82例作为研究对象,按照入院顺序分为观察组和对照组,每组各41例,两组入选患者均给予常规抗心力衰竭治疗,在此基础上对照组予以硝酸甘油治疗,观察组予以新活素治疗,观察治疗调整前后对比两组患者的心功能、N端-B型脑利钠肽前体(NT-proBNP)及临床疗效.结果 治疗前两组患者的左室射血分数(LVEF)、左心室舒张末内径(LVDd)及血浆NT-proBNP比较,差异无统计学意义(P>0.05);治疗后观察组患者与治疗前比较LVEF、LVDd及NT-proBNP水平均明显改善,与对照组比较,观察组LVEF、LVDd及NT-proBNP水平改善更为明显,P<0.05,差异均具有统计学意义.观察组临床总有效率为92.11%,明显高于对照组的73.17%,P<0.05,差异均有统计学意义.结论 新活素对老年失代偿性心力衰竭患者临床疗效显著,可明显改善心功能水平及心室重塑.%Objective To investigate the influence of recombinant human brain natriuretic peptide (rhBNP) on heart function in elderly patients with decompensated heart failure (DHF). Methods Elderly DHF patients (n=82) were chosen from the Department of Geriatrics of Chinese PLA 464 Hospital from Mar. 2013 to May 2017, and divided, according to order of hospitalization, into observation group and control group (each n=41). All patients in 2 groups were treated with routine anti-heart failure therapy, and control group was additionally given nitroglycerin (NTG) and observation group, additionally, rhBNP. The heart function, level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and clinical efficacy were observed and compared in 2 groups. Results The comparison in left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDd) and NT-proBNP showed that difference had no statistical significance (P>0.05). LVEF, LVEDd and NT-proBNP were significantly improved in observation group after treatment, which was more significant in observation group than that in control group (P<0.05). The total clinical efficacy was 92.11% in observation group and 73.17% in control group (P<0.05). Conclusion RhBNP has significant clinical efficacy, and can improve heart function and relieve ventricular remodeling in elderly DHF patients.