核转录因子κB基因多态性与人群感染丙型肝炎病毒的关联性

摘要

Objective To explore the association between nuclear factor kappa-light-chainenhancer of activated genetic polymorphisms in B cells (NF-κB) and the HCV susceptibility,among the Chinese population.Methods A total of 1 679 participants were enrolled;including 503 drug users and 1 176 other participants at risk under the exposure for blood.By using the logistic regression analysis,related risk factors for HCV infection among subjects were analyzed.Two NF-κB pathway variants,NF-κB1 rs72696119 and REL rs13031237 were then genotyped by TaqMan assay method.Logistic regression analysis was performed to analyze the association between gene polymorphisms and the susceptibility on HCV.Results Among the drug users,women (OR=0.408,95％CI:0.308-0.767) appeared to be associated with the decreased risk for HCV infection,while factors as drug injection (OR=8.817,95％CI:5.577-13.937) and the duration of drug-intake ＞5.5 years (OR=2.891,95％CI:1.824-4.583) were associated with the increased risk for HCV infection.Among the participants who had been exposed to blood,women (OR=3.431,95％ CI:2.360-4.988) were associated with the increased risk for HCV infection,while the levels of education beyond elementary school (OR =0.613,95％ CI:0.429-0.876) were associated with the decreased risk for HCV infection.Compared to the reference NF-κB1 rs72696119 CC genotype,the carriage of GG genotype was associated with an increased risk of susceptibility on HCV (OR=1.412,95％ CI:1.035-1.927) among the total study population.Results from the interaction analysis showed that there was no interactive effects appeared between rs72696119 and route of infection,or between rs72696119 and gender among the total population under study (all P＞0.05).Conclusion NF-κB1 polymorphism rs72696119 and related factors seemed associated with the susceptibility to HCV infection among high-risk Chinese populations.%目的 探索核转录因子κB(NF-κB)基因多态性与人群感染HCV的关联性.方法 本研究共纳入1 679位研究对象(503位吸毒者和l 176位高危血源性暴露者).通过logistic回归分析人群感染HCV的相关因素,通过TaqMan-MGB探针法对NF-κB1基因rs72696119和REL基因rs13031237位点进行基因分型,并分析其与HCV易感性的相关性.结果 在吸毒人群中,女性吸毒者(OR=0.408,95％CI:0.308～0.767)HCV易感性更低,而静脉注射吸毒(OR=8.817,95％CI:5.577 ～ 13.937)以及吸毒时间＞5.5年(OR=2.891,95％CI:1.824 ～ 4.583)则是感染HCV的危险因素.在高危血源暴露人群中,小学以上文化程度(OR=0.613,95％CI:0.429～ 0.876)是该高危人群感染HCV的保护因素,而女性(OR=3.431,95％CI:2.360～ 4.988)则是感染HCV的危险因素.在总人群中,携带NF-κB1 rs72696119 GG基因型的个体更易感染HCV(OR=1.412,95％CI:1.035～1.927).总人群中的交互作用分析显示,rs72696119与HCV感染途径、性别均不存在交互作用(P＞0.05).结论 在高危人群中,相关的行为因素和NF-κB1基因rs72696119多态性与HCV易感性相关.