理想心血管健康行为和因素与非酒精性脂肪肝的相关性研究

摘要

目的 探讨理想心血管健康行为和因素与非酒精性脂肪肝(NAFLD)的关系.方法 以参加2006-2007年度健康体检的101 510名开滦集团公司职工为研究对象,排除饮酒者、心肌梗死、脑卒中、恶性肿瘤以及资料不全者,最终纳入54 303例,观察研究人群中NAFLD的患病情况.根据美国心脏协会定义的理想心血管健康行为和因素,采用多因素logistic回归模型分析理想心血管健康行为和因素与NAFLD的关系.结果 具备0～1、2、3、4、5～7个理想心血管健康行为和因素组的NAFLD患病率分别为62.6％、48.9％、33.3％、16.1％和7.5％ (P＜0.000 1).校正年龄、性别、经济收入水平、文化程度等混杂因素后,理想心血管健康行为和因素与NAFLD有关,且随着健康行为和因素个数的增多(0～1、2、3、4、5～7),OR值(95％CI)逐渐降低,分别为1、0.61(0.56～0.66)、0.37(0.34～0.40)、0.17(0.15 ～0.18)和0.08(0.07 ～0.09).结论 理想心血管健康行为和因素与NAFLD相关.%Objective To investigate the relationship between ideal cardiovascular behaviors/ factors and nonalcoholic fatty liver disease.Methods In our study,54 303 workers who had participated in the 2006-2007 Kailuan health examination with complete data and without history of drinking,myocardial infarction,stroke or cancer,were recruited.All workers were under observation and their prevalence of nonalcoholic fatty liver disease recorded.According to the American Heart Association defmition of ideal cardiovascular health behaviors and factors,multiple logistic regression method was used to calculate the OR and 95％ CI for baseline behaviors and factors.Results The prevalence of nonalcoholic fatty liver disease according to 0-1,2,3,4,5-7 ideal cardiovascular health behaviors/factors were 62.6％,48.9％,33.3％,16.1％ and 7.5％,respectively.Results from the logistic model showed that after adjustment for age,gender,income,education level and other confounders,the ideal cardiovascular health behaviors/factors were associated with nonalcoholic fatty liver disease and the ORs (95％ CI) were reduced gradually with the increase of ideal cardiovascular health behaviors/factors,which were 1,0.61 (0.56-0.66),0.37 (0.34-0.40),0.17 (0.15-0.18) and 0.08 (0.07-0.09),respectively,in the 2,3,4,5-7 ideal behaviors/factors groups.Conclusion Ideal cardiovascular health behaviors and factors were associated with nonalcoholic fatty liver disease.