妊娠意愿与孕中晚期妊娠相关焦虑关联的队列研究

摘要

目的 探讨妊娠意愿与孕中、晚期妊娠相关焦虑关联及其强度.方法 在马鞍山优生优育队列(MABC)中,将孕周≤14周、符合纳入标准的3 474名孕妇纳入队列.在首次产检时收集孕妇的一般人口学信息,并在孕中期和孕晚期收集妊娠相关焦虑量表.采用logistic回归分析妊娠意愿对孕中期和孕晚期妊娠相关焦虑的影响.结果 最终3 083人纳入分析,意外妊娠检出率为15.00％(n=461).孕中期和孕晚期妊娠相关焦虑检出率分别为29.13％(n=898)、30.36％(n=936).控制潜在的混杂因素后,与有充分思想准备的孕妇相比,意外妊娠的孕妇孕中期出现妊娠相关焦虑的风险增加(OR=1.85,95％CI:1.44 ～ 2.38);孕晚期出现妊娠相关焦虑的风险也增加(OR=1.84,95％CI:1.44～ 2.35);顺其自然怀孕的孕妇在孕中、晚期未增加妊娠相关焦虑发生风险.结论 意外妊娠是孕中、晚期妊娠相关焦虑危险因素.%Objective To understand the association between pregnancy intention and pregnancy-related anxiety in the second and third trimester and its strength.Methods A prospective cohort study was conducted in Ma' anshan,Anhui province.A total of 3 474 eligible pregnant women within 14 weeks of gestation were recruited.The information about their demographic characteristics were collected in early pregnancy.The completed questionnaire of pregnancy-related anxiety were asked to return in the second and third trimester.Logistic regression analysis was conducted to evaluate the association between pregnancy intention and pregnancy-related anxiety in the second and third trimester.Results A total of 3 083 pregnant women were included in final analysis,The rate of unintentional pregnancy was 15.00％ (n=461).The detection rates of pregnancy-related anxiety in the second and third trimester were 29.13％ (n=898) and 30.36％ (n=936).After controlling potential confounding factors,unintentional pregnancy increased the risk of pregnancy-related anxiety in the second trimester compared with intentional pregnancy (OR=1.85,95％ CI:1.44-2.38);The risk of pregnancy-related anxiety also increased in the third trimester (OR=1.84,95％ CI:1.44-2.35).Intentional pregnancy did not increase the risk of pregnancy-related anxiety in the second and third trimester.Conclusion The study results suggests that unintentional pregnancy could increase the risk of pregnancy-related anxiety in the second and third trimester.