Graves眼病活动期患者糖皮质激素治疗前后血清8-羟基脱氧鸟嘌呤水平临床对照研究

摘要

The change in serum level of 8-hydroxy-deoxyguanosine (8-OHdG),an oxidative stress biomarker,in patients with active Graves' ophthalmopathy (GO) during corticosteroid treatment was observed.The serum level of 8-OHdG was significantly increased in patients with active GO as compared with that of normal controls and patients with Graves' disease (P ＜ 0.05).After systemic corticosteroid treatment,patients with GO showed significantly lowered 8-OHdG level as compared with that before treatment and patients with Graves' disease.These changes in serum 8-OHdG level were accompanied by decreases in clinical activity score (P ＜ 0.05) during corticosteroid treatment.Oxidative stress may play a role in the pathogenesis of GO.Serum 8-OHdG level may be used as an objective and quantitative parameter in patients with GO during immunosuppressive treatment.%探讨氧化应激DNA损伤水平在活动性Graves眼病(Graves' ophthalmopathy,GO)患者经糖皮质激素治疗后的变化情况.与对照组和Graves病(GD)组相比,GO组的血清8-羟基脱氧鸟嘌呤(8-hydroxy-deoxyguanosine,8-OHdG)显著增高(P＜0.05);GO患者经糖皮质激素治疗后血清8-OHdG水平及临床疾病活动分数(clinical activity score)较治疗前显著降低(P＜0.05);治疗后的血清8-OHdG水平低于GD组(P＜0.05).氧化应激参与GO的发病,GO患者的血清8-OHdG水平经糖皮质激素治疗后明显下降,可作为判断GO治疗效果的良好指标.