1例53岁女性患者因确诊右下肺腺癌入院，经多方案化疗疗效欠佳，后改为培美曲塞与吉非替尼序贯治疗。应用吉非替尼16 d后，患者出现间断性发热，咳少量白色黏液痰，最高体温39℃，查胸部CT提示：双肺多见弥漫性浸润性阴影伴少量胸腔积液，给予抗感染、化痰等对症治疗后症状未缓解，评估疾病状态，排除肺癌进展，考虑为吉非替尼所引发的间质性肺炎。给予醋酸泼尼松片对症治疗37 d，患者复查胸部CT示双肺间质炎症较前吸收。之后患者未再服用吉非替尼，10 d后再次入院进行评估，改用埃克替尼控制疾病进展，随访2个月未再出现发热、咳嗽咳痰等症状。%One 53-year-old female patient was diagnosed with the right lower lung adenocarcinoma. After several rounds of unsuccessful chemotherapies, the patient received sequential therapy of pemetrexed and geiftinib. Application of geiftinib 16 days later, the patient presented with intermittent fever, cough a few white mucus, and highest temperature of 39℃. Diffuse inifltration shadow can be seen along with a small amount of pleural effusion by CT examination. The patient was treated with anti-infective and other symptomatic treatment, but the symptoms were not alleviated. After assessment of disease state, the lung cancer progression was excluded, then the symptoms were considered as geiftinib-induced interstitial pneumonia. The patient was received prednisone acetate tablets for the treatment of interstitial pneumonia for 37 days, the chest CT examination showed bilateral pulmonary interstitial inlfammation had been absorbed. The patient has no longer taken geiftinib. After 10 days, the patient readmitted to hospital for disease assessment. Finally, the patient took icotinib to control the disease progression, and no fever, coughing sputum and other symptoms were observed in the following next 2 months.
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