Objective To investigate the expression characteristic of CD90 in human hepatocellular carcinoma ( HCC ) tissues, adjacent noncancerous hepatic tissues and normal hepatic tissues, and to explore the effect of CD90 in the development and progression of HCC. Methods The expression of CD90 in HCC tissues, adjacent noncancerous hepatic tissues and normal hepatic tissues adjacent hepatic hematoma were measured by immunohistochemical staining, the relationship between expression of CD90 and clinicopathological parameters was analyzed. Results The immunohistochemical staining results showed that the CD90 expression in HCC tissues was significantly higher than that in adjacent noncancerous hepatic tissues and in normal hepatic tissues ( Z = -7.018, P =0.000 and Z = -6.234, P =0.000), in adjacent noncancerous hepatic tissues was significantly higher than that in normal hepatic tissues ( Z = -2. 619, P =0.009 ). The expression of CD90 in HCC tissues had relationship with the sizes of tumor, metastasis, clinical stages and pathological classification ( Z = -2.038, P = 0.042;Z= -3.041, P =0.002;x2 =10.771, P =0. 029 ;x2 =9.357, P =0.009). While it had no significant difference referred to the sex,age, AFP, HBsAg, HBeAg( Z = - 0. 816, P = 0. 414;Z = - 0. 618, P = 0. 536; Z = - 1. 372, P = 0.170; Z = - 1.057, P = 0.291; Z = - 1.355, P = 0. 175 ). Conclusion The expression of CD90 in HCC tissue was up-regulated, which had closely relationship with the biological behavior of HCC patients. The CD90 may be an effective indicator in evaluating the prognosis of HCC patients.%目的 研究CD90在人肝细胞癌组织、癌旁硬化肝组织及正常肝组织中的表达特点,以了解其在肝癌发生发展中的作用.方法 应用免疫组织化学法检测CD90在人肝细胞癌组织、癌旁硬化肝组织及肝血管瘤周边正常肝组织标本中的表达,并分析其与肝癌临床病理学参数的相关性.结果 CD90在肝癌组织的表达显著高于癌旁硬化肝组织和正常肝组织(Z=-7.018,P=0.000和Z=-6.234,P=0.000),在癌旁硬化肝组织的表达显著高于正常肝组织(Z=-2.619,P=0.009);对临床病理学资料的统计分析显示,CD90在肝癌组织中的表达与肿瘤大小、转移情况、临床分期、病理分级相关(Z=-2.038,P=0.042;Z =-3.041,P= 0.002;χ2=10.771,P= 0.029;χ2=9.357,P=0.009);与患者性别、年龄、AFP、HBsAg、HBeAg无关(Z=-0.816,P=0.414;Z=-0.618,P=0.536;Z=-1.372,P=0.170;Z=-1.057,P=0.291;Z=-1.355,P=0.175).结论 CD90在肝癌组织的表达明显上升,其在肝癌组织的表达与肝癌的生物学行为密切相关,可作为肝癌患者预后评估的有效指标.
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