Objective To investigate the relationship between respiratory tract bacterial colonization and inflammatory cells in patients with stable COPD. Methods 100 patients with stable COPD were chosen, sputum IL-8, IL-6 and TNF-α were measured, lung function were detected. Lower respiratory tract colonization of patients was observed. Sputum cytokine of bacterial counts ≥ 107 CFU/ml and < 107 CFU/ml patients were compared. The relationship between lung function and lower re-spiratory tract bacterial colonization were observed. Results Haemophilus influenza accounted for the most counts, followed by streptococcus pneumonia. In patients whose number of bacteria≥ 107CFU/ml, IL-8, IL-6 and TNF-α were significantly higher than those < 107 CFU/ml ( P < 0.05 ). After 1 year follow up, patients whose number of bacteria≥ 107 CFU/ml, FEV1 decline, FEV, pre changes and the numbers of acute exacerbation were significantly larger than those < 107CFU/ml ( P < 0.05). The number of lower respiratory tract bacterial colonization in patients whose FEV, < 50% significantly greater than those whose FEV1 ≥50% ( P <0.05). Conclusion Airway bacterial colonization can aggravate stable the chronic obstructive pulmonary disease in patients with airway inflammation, with the colonization of bacteria increased in the number, patients ' lung function decreased significantly.%目的 探讨稳定期慢性阻塞性肺疾病(COPD)患者呼吸道细菌定植与炎性细胞的关系.方法 选择稳定期COPD患者100例,收集痰液标本,测定痰液内IL-8、IL-6及TNF-α水平,检测患者肺功能.观察稳定期COPD患者下呼吸道细菌定植情况.比较细菌数量≥107CFU/ml者及<107 CFU/ml者痰液细胞因子测定结果,分析患者肺功能与下呼吸道细菌定植的关系.结果 呼吸道定植菌以流感嗜血杆菌最多,其次为肺炎链球菌.细菌数量≥107 CFU/ml者,IL-8、IL-6及TNF-α水平均显著高于细菌数量<107 CFU/ml者(P<0.05).随访1年,细菌数量≥107CFU/ml者,FEV1下降值及FEV,预计值变化显著高于细菌数量<107 CFU/ml者,急性加重次数显著多于细菌数量< 107 CFU/ml者(P<0.05).FEV1<50%预计值患者下呼吸道细菌定植数量显著高于FEV1≥50%预计值者(P<0.05).结论 下呼吸道细菌定植可以加重稳定期COPD患者气道炎性反应,随定植细菌数量增多,患者发生急性加重次数增加,肺功能降低明显.
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