氨氯地平联合卡托普利治疗原发性高血压有效性与安全性的 Meta 分析

摘要

Objective To assess the efficacy and safety of amlodipine plus captopril for the treatment of essential hy -pertension.Methods Retrieval review published paper in Chinese Biomedical Literature Database ( 1978-December, 2013 ) , China Academic Journal ( 1994-December , 2013 ) , VIP database ( 1999-December , 2013 ) , Articles Database (1990-December, 2013), PUBMED (1990-December, 2013), Cochrane Library (December, 2013).Included amlodip-ine and captopril ( combined group ) with captopril alone ( monotherapy ) treatment of essential hypertension randomized con-trolled trials, the researchers from the two independent screening and extract data , using Jadad quality score quality of the studies included in the review, using RevMan5.2 for the Meta-analysis.Results 355 papers were retrieved, according to the inclusion and exclusion criteria , finally included 12 paper for Meta-analysis.Meta-analysis: effectiveness of the combined group is higher than the monotherapy group , the difference was statistically significant (OR=4.06,95% CI 2.85-5.79, P <0.01);incidence of adverse reactions in combined group and monotherapy group showed no statistically significant differ -ences (OR =1.35, 95% CI 0.35-5.14, P =0.66).Conclusion Amlodipine combining captopril has better curative effect than single captopril in the treatment of hypertension , but the safety has no obvious difference .%目的：系统评价氨氯地平联合卡托普利治疗高血压病的有效性及安全性。方法检索中国生物医学文献数据库（1978-2013年12月）、中国期刊全文数据库（1994-2013年12月）、维普数据库（1999-2013年12月）、万方数据库（1990-2013年12月）、PUBMED（1990-2013年12月）、Cochrane Library（2013第12期）。纳入氨氯地平联合卡托普利（联合组）与单用卡托普利（单药组）治疗原发性高血压的随机对照试验，由2位研究员独立筛选并提取资料，采用Jadad质量评分评价纳入研究的质量，采用RevMan5篌．2进行Meta分析。结果共检索到文献355篇，按照纳入和排除标准，最终筛选12篇进行Meta 分析。 Meta 分析结果：联合组有效性高于单药组，差异有统计学意义（OR＝4．06，95％CI 2．85～5．79， P ＜0．01）；联合组不良反应发生率与单药组比较差异无统计学意义（OR＝1．35，95％CI 0．35～5．14， P ＝0．66）。结论氨氯地平联合卡托普利治疗高血压的疗效优于单用卡托普利，但安全性二者无显著差异。