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A multicenter randomized and double-blind phase IV clinical trial to compare the efficacy and safety of fixed-dose combinations of amlodipine orotate/valsartan 5/160 mg versus valsartan/hydrochlorothiazide 160/12.5 mg in patients with essential hypertension uncontrolled by valsartan 160 mg monotherapy

机译：一项多中心随机双盲IV期临床试验比较了氨氯地平乳清酸/缬沙坦5 /160μmg与缬沙坦/氢氯噻嗪160 /12.5μmg固定剂量联合用药在不受缬沙坦160控制的原发性高血压患者中的疗效和安全性毫克单药

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Background:To determine whether the effectiveness and safety of fixed-dose combinations (FDCs) of amlodipine orotate/valsartan (AML/VAL) 5/160 mg are noninferior to those of valsartan/hydrochlorothiazide (VAL/HCTZ) 160/12.5 mg in hypertensive patients with inadequate response to valsartan 160 mg monotherapy.

机译：背景：确定高血压的氨氯地平/缬沙坦（AML / VAL）5/160 mg的固定剂量组合（FDCs）在高血压方面的疗效和安全性是否不低于缬沙坦/氢氯噻嗪（VAL / HCTZ）160 / 12.5 mg的有效性和安全性对缬沙坦160 mg单一疗法反应不足的患者。

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期刊名称 other
作者
Youngkeun Ahn; Yongcheol Kim; Kiyuk Chang; Weon Kim; Moo-Yong Rhee; Kwang Soo Cha; Min Su Hyon; Chi Young Shim; Sung Yun Lee; Doo Il Kim; Sang Wook Kim; Sang-Wook Lim; Kyoo-Rok Han; Sang-Ho Jo; Nae-Hee Lee; Jun Kwan; Taehoon Ahn;
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年(卷),期 -1(97),37
年度 -1
页码 e12329
总页数 8
原文格式 PDF
正文语种
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关键词
amlodipine orotate fixed-dose combination hypertension valsartan;

机译：氨氯地平乳清酸盐;固定剂量联合用药;高血压;缬沙坦;
入库时间 2022-08-21 11:06:45

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1. Comparison of the Efficacy and Safety Profiles of Two Fixed-Dose Combinations of Antihypertensive Agents, Amlodipine/Benazepril Versus Valsartan/Hydrochlorothiazide, in Patients With Type 2 Diabetes Mellitus and Hypertension: A 16-Week, Multicenter, Randomized, Double-Blind, Noninferiority Study [J] . LeeI.-T., HungY.-J., ChenJ.-F., Clinical therapeutics . 2012,第8期

机译：两种固定剂量抗高血压药氨氯地平/贝那普利与缬沙坦/氢氯噻嗪对2型糖尿病和高血压患者的疗效和安全性比较：一项为期16周的多中心随机双盲非劣效性研究
2. Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study [J] . Sang-Hyun Ihm, Hui-Kyung Jeon, Tae-Joon Cha, Drug Design, Development and Therapy . 2016,第5期

机译：S-氨氯地平和替米沙坦的两种固定剂量组合（CKD-828）与S-氨氯地平单药治疗在S-氨氯地平单药治疗不能有效控制的高血压患者中的疗效和安全性：8周，多中心，随机，双盲， III期临床研究
3. Evaluation of the Efficacy and Safety of the Lercanidipine/Valsartan Combination in Korean Patients With Essential Hypertension Not Adequately Controlled With Lercanidipine Monotherapy: A Randomized, Multicenter, Parallel Design, Phase III Clinical Trial [J] . Na Sang-Hoon, Lee Hae-Young, Baek Sang Hong, Clinical therapeutics . 2015,第8期

机译：Lercanidipine / Valsartan联合治疗对原发性高血压未完全控制的Lercanidipine单药治疗的韩国患者的疗效和安全性评估：一项随机，多中心，并行设计的III期临床试验
4. Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week multicenter randomized double-blind Phase III clinical study [O] . Sang-Hyun Ihm, Hui-Kyung Jeon, Tae-Joon Cha, 2016

机译：S-氨氯地平和替米沙坦的两种固定剂量组合（CKD-828）与S-氨氯地平单药治疗在S-氨氯地平单药治疗不能充分控制的高血压患者中的疗效和安全性：8周多中心随机双盲 III期临床研究
5. Valsartan 160 mg/Amlodipine 5 mg Combination Therapy versus Amlodipine 10 mg in Hypertensive Patients with Inadequate Response to Amlodipine 5 mg Monotherapy [O] . Jidong Sung, Jin-Ok Jeong, Sung Uk Kwon, 2016

机译：缬沙坦160毫克/氨氯氨阶5毫克组合治疗与氨氯地平10毫克在高血压患者中，对氨氯地平5毫克单药治疗的反应不足

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