目的研究胰岛素受体底物1(IRS-1)基因Gly972Arg突变与中国人糖尿病的相关性。方法随机选取上海地区中国人359例,用PCR/BstN1酶解法检测Gly972Arg突变。结果本组中国人中仅发现2例该突变且均为非糖尿病者。结论该突变可能不是中国人糖尿病的重要遗传因素。%Objective To investigate whether the Gly972Arg mutation of the insulin receptor substrate 1(IRS1)gene associates with type 2 diabetes in Chinese.Methods Gly972Arg mutation of IRS1 gene was determined by PCR/BstN1 digestion in a group of 359 subjects.Results Only two subjects with Gly972Arg mutation were found in the study group.Conclusion Gly972Arg mutation of IRS1 gene may not be a major genetic factor for type 2 diabets in Chinese.
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