空腹血糖控制对糖尿病治疗的临床意义

摘要

Although the newly developed anti-diabetic drugs are emerging, the glycemic control is still poor. Moreover, there is a wide gap of understanding the critical role of basal insulin in improving the BG control of type 2 diabetes mellitm (T2DM). Numerous studies have confirmed that the treatment and controlling fasting plasma glucose (FPG) with basal insulin have favorable therapeutic effect on improving the full-day glycemic spectrum, lowing the risks of complications of DM, and protecting β-cells. The review here intends to provide an overview of the clinical significance of basal insulin in patients with T2DM for the FFG control.%根据一项涵盖17个国家(含中国)、纳入9901例T2DM患者的国际糖尿病治疗实践研究(IDMPS)结果显示,HbA1c未达标(≥7％)者高达63.6％,这与临床医生对胰岛素治疗及血糖控制目标上存在认识误区不无关系.大量研究结果证实,基础胰岛素治疗是T2DM治疗中极具潜力的治疗手段,它首先通过有效控制FPG进而达到改善全天血糖谱、降低DM并发症风险,并保护胰岛β细胞功能的目的.本文就近年来这一领域的一些观念和循证依据对DM治疗中FPG的意义加以探讨.