目的 探讨血清巨噬细胞抑制因子-1 (MIC-1)水平与T2DM及超重的相关性及其临床意义. 方法 纳入91例新诊断T2DM患者(T2DM组)和80名NGT者(NGT组).按BMI分为体重正常(B、D)组和超重(A、C)组.采用ELISA法测定MIC-1水平. 结果 T2DM组MIC-1浓度高于NGT组(P＜0.05).相关性分析显示,T2DM组中MIC-1与TG呈正相关,与HDL-C呈负相关.HDL-C是MIC-1的独立相关因素. 结论 T2DM患者MIC-1水平升高,可能参与了脂代谢异常的形成.%Objective To evaluate the change of serum macrophage inhibitory cytokine-1 (MIC-1) in T2DM and its clinical significance. Methods Ninety-one newly diagnosed T2DM patients and 80 subjects with NGT were enrolled and each group was divided into normal weight and overweight subgroups according to BMI < or ≥25 kg/m2. The level of serum MIC-1 was measured by enzyme-linked immunosorbent assay. Results The level of MIC-1 in T2DM group was higher than in NGT group (F< 0. 05). Simple correlation analysis showed that in the T2DM group the MIC-1 was positively correlated with TG, and negatively with HDL-C Furthermore, multivariate regression analysis showed that HDL-C was the independent relative factor of serum MIC-1 level. Conclusion In the T2DM patients, the increased MIC-1 may be involved in the formation of metabolism turbulence of lipid.
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