Objective To explore the correlation between glucose level and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus. Methods All the subjects were divided into two groups :normal control group (NC ,n=240) and T2DM group (T2DM ,n=350). Patients in T2DM group were further divided into three subgroups according to HbA 1 c level:6.0% ≤ HbA1 c<7.0% subgroup , 7.0% ≤ HbA1c < 8.0% subgroup and HbA1c ≥ 8.0% subgroup. Duration of T2DM ,BMI ,FPG and HbA1c were collected and compared between two groups. The correlation between HbA1c level and various cardiovascular indicators was analyzed. Results FPG ,TG ,TC ,LDL-C ,24 hPP ,LVM and NT-proBNP were significantly higher while E/A ,LVEF and HDL-C were significantly lower in T2DM group than in NC group (P< 0.05).FPG ,24 hPP ,LVM ,NT-proBNP ,SBP and TC were significantly higher while E/A and LVEF were significantly lower in 7.0% ≤ HbA1c<8.0% subgroup than in 6.0% ≤HbA1c<7.0% subgroup(P< 0.05). FPG ,24 hPP ,LVM ,NT-proBNP ,SBP ,DBP ,TC ,TG and LDL-C were significantly higher while E/A ,LVEF and HDL-C were significantly lower in HbA1c≥8.0% subgroup than in 7.0% ≤HbA1c<8.0% subgroup (P<0.05). Correlation analysis showed that HbA1c level was positively correlated with 24 hPP ,LVM and BNP and negatively correlated with E/A and LVEF. Multiple regression analysis showed that HbA1c level was a cardiovascular risk factor for elderly patients with T2DM. Conclusion Damage to cardiovascular system in elderly patients with T 2DM is particularly obvious when the patients were at poor glycemic control. T2DM and poor control of HbA1c level are independent risk factors for cardiovascular disease.%目的：探讨T2DM患者心血管病危险因素与不同血糖水平的相关性。方法选择健康对照（NC）者240名，T2DM 组350例。收集两组病程、BMI、FPG及 HbA1c等水平，并进行比较，分析HbA1 c与心血管各项指标的相关性。结果 T2DM组FPG、TG、TC、LDL-C、24 h平均脉压（PP）、左室重量（LVM）和B型脑钠肽前体（NT-proBNP）较NC组升高，左室舒张早期与晚期二尖瓣最大血流速比值（E／A）、左室射血分数（LVEF）、HDL-C较NC组降低（P＜0.05）。7.0％≤ HbA1c＜8.0％亚组FPG、24 hPP、LVM、NT-proBNP、SBP、TC较6.0％≤ HbA1c＜7.0％亚组升高，E／A、LVEF降低（P＜0.05）。HbA1c≥8.0％亚组 FPG、24 hPP、LVM、NT-proBNP、SBP、DBP、TC、TG、LDL-C较7.0％≤ HbA1c＜8.0％亚组升高，E／A、LVEF、HDL-C降低（P＜0.05）。相关分析显示，HbA1c与24 hPP、LVM 及 NT-proBNP呈正相关，与E／A及LVEF呈负相关。结论 T2DM患者在血糖控制不佳时易发生心血管系统损害。T2DM和 HbA1 c控制差均是心血管疾病发生的独立危险因素。
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