目的：探讨DPN患者颈动脉内‐中膜厚度（CIMT）、颈动脉僵硬度与HbA1c的关系。方法选取T2DM组60例、DPN组100例及健康体检者（NC）60名，测定HbA1c水平、CIMT和颈动脉僵硬度。结果DPN组HbA1c[（8.62±2.71）％vs（4.20±0.47）％，（7.59±1.98）％]，CIMT[（1.01±0.11）vs（0.70±0.07），（0.81±0.09）mm]和颈动脉硬度[（827.6±123.7）vs（521.2±89.3），（629.3±113.5）]高于NC、T2DM组（P＜0.05）；DPN组病程高于T2DM组（P＜0.05）；DPN组HbA1c≥10.0％亚组CIMT[（1.11±0.09）vs（0.94±0.07），（0.73±0.06）mm]和颈动脉僵硬度[（901.5±241.5）vs（724.5±159.9），（574.1±145.3）]高于8.0％≤HbA1c＜10.0％亚组和7.0％≤HbA1c＜8.0％亚组（P＜0.05）；相关分析结果显示，HbA1c与CIMT、颈动脉僵硬度呈正相关（r＝0.107、0.213，P＜0.05）。结论DPN患者CIMT、颈动脉僵硬度与HbA1c呈正相关，且HbA1c是CIMT和颈动脉僵硬度的危险因素。%Objective To explore the relationship between HbA1 c and carotid artery intima‐media thickness (CIMT) ,carotid arterial stiffness in diabetic patients with peripheral neuropathy. Methods A total of 220 subjects were enrolled in this study and divided into three groups:T2DM group (n=60) ,DPN group (n=100) ,and healthy individuals as NC group (n=60). Serum HbA1c ,CIMT and carotid arterial stiffness were measured. Results HbA1c [(8.62 ± 2.71)% ] ,CIMT [(1.01 ± 0.11)mm] and carotid arterial stiffness [(827.6 ± 123.7)]was significantly higher in DPN group than in NC group [(4.20 ± 0.47)% ,(0.70 ± 0.07) mm ,(521.2 ± 89.3)] and T2DM group [(7.95 ± 1.98) % ,(0.81 ± 0.09) mm , (629.3 ± 113.5)] respectively (P< 0.05).The duration was significantly longer in DPN group than in T2DM group(P<0.05). CIMT [(1.11 ± 0.09)mm] and arotid arterial stiffness [(901.5 ± 241.5)] was higher in patients with HbA1 c≥10.0% than in patients with HbA1 c between 8.0% ~10.0% [(0.94 ± 0.07)mm ,(724.5 ± 159.9)] and patients with HbA1c between 7.0% ~ 8.0% [(0.73 ± 0.06)mm , (574.1 ± 145.3 )] respectively ( P< 0.05 ).Association analysis showed that HbA1 c had a positive correlation with CIMT and carotid arterial stiffness (r= 0.107 ,0.213 ,P< 0.05). Conclusion CIMT and carotid stiffness are positively correlated with HbA1 c in DPN patients.HbA1 c is a risk factor for CIM T and carotid stiffness.
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