血清载脂蛋白B、甘油三酯、脂蛋白a和转铁蛋白与2型糖尿病视网膜病变的相关性研究

摘要

目的 探讨T2DM患者血清载脂蛋白B(ApoB)、脂蛋白a(Lp-a)、TG和转铁蛋白(TRF)的变化与DR的相关性. 方法 回顾性分析150例T2DM住院患者临床资料,根据眼底检查结果分为单纯T2DM组80例和DR组70例,相关血清指标行独立样本t检验,对有统计学差异的指标行多元Logistic回归分析. 结果 与T2DM组比较,DR组糖尿病病程长,血清ApoB、TG、Lp-a和胱抑素(Cys)水平升高(P<0.05或P<0.01),血清TRF水平降低(P<0.01);Logistic回归分析结果显示,糖尿病病程、ApoB、TG及Lp-a为DR的危险因素(OR 1.267、11.237、1.618、1.002,P<0.05或P<0.01),TRF为DR的保护性因素(OR 0.432,P<0.01). 结论 血清ApoB、TG、Lp-a和TRF代谢异常与DR关系密切,可能参与了DR的发生发展.%Objective To investigate the correlation of serum apolipoprotein B (ApoB),triglyceride (TG),lipoprotein a(Lp-a) and transferrin(TRF) with diabetic retinopathy(DR) in type 2 diabetes mellitus(T2DM).Methods The clinical data of 150 patients with T2DM were retrospectively analyzed.150 T2DM patients were divided into T2DM group (n=80) and DR group (n=70),according to their fundus photography.The relevant serum parameters were tested by t-test,and the statistically significant indexes were analyzed by logistic regression analysis.Results Compared with T2DM group,the course of diabetes was longer,the concentrations of ApoB,TG,Lp-a and cystatin (Cys) were increased (P<0.05 or P<0.01),serum TRF were decreased (P<0.01)in DR group.Logistic regression analysis showed that the course of diabetes,serum ApoB,TG and Lp-a were the risk factors of DR (OR 1.267,11.237,1.618,1.002,P<0.05 or P<0.01),TRF was the protective factor of DR (OR 0.432,P<0.01).ConclusionAbnormality of serum ApoB,TG,Lp-a and TRF is correlated with DR and might be involved in the development of DR.