玫瑰糠疹患者不同时期血清白细胞介素4、白细胞介素12和干扰素γ水平检测

摘要

Objective To investigate expression of cytokines, such as serum interleukin-4(IL-4), interleukin-12(IL-12), and interferon-γ (IFN-γ) from pityriasis rosea (PR) patients in different stages. Methods Double antibody sandwich-type enzyme-linked immunosorbent assay(ELISA) was used. Results The level of IL-4 was higher in restoration stage patients(P< 0.05 ), which was close to healthy control (P<0.05 ); while IL-12 and IFN-γ level was lower in restoration stage patients (P< 0.05 ), which was close to healthy control(P<0.05). Conclusion There is unbalance of humoral immunity in acute stage of PR.%目的 观察玫瑰糠疹患者急性期和恢复期血清中白细胞介素4(interleukin-4,IL-4)、白细胞介素12(interleukin- 12,IL-12)、干扰素γ(interferon-γ,IFN-γ)表达水平.方法 应用双抗体夹心酶联免疫吸附试验(enzymelinked immunosorbent assay,ELISA)方法.结果 玫瑰糠疹患者恢复期血清中IL-4水平较急性期升高(P＜0.05),恢复期与正常对照组IL-4表达水平接近(P＞0.05)；玫瑰糠疹患者恢复期血清中IL-12、IFN-r水平较急性期降低(P＜0.05),而IL-12、IFN-r水平与正常对照组接近(P＞0.05).结论 玫瑰糠疹患者在急性期体内存在免疫失衡.