Interleukin 12 Induction of Interferon Gamma-Dependent Protection Against Malaria

摘要

Intraperitoneal Injection of recombinant Interleukin 12 (rIL-12) at 30 ng/day for5 days beginning 1 to 2 days before sporozoite challenge or administration of a single dose of 150 ng of rIL-122 days before challenge protected 100% of BALB/c mice against challenge with 102 Plasmodium yoelii sporozoites. rIL-12-induced protection was eliminated in all mice by administration of a monoclonal antibody against interferon y and in 50% of mice by administration of NG-monomethyl-L-arginine, a competitive inhibitor of nitric oxide synthase. rIL-12 protected BALB/c mice treated wjth cytotoxic anti-CD4 and anti-CD8 monoclonal antibodies,