目的 探讨同型半胱氨酸(HCY)和尿酸(UA)在寻常型银屑病及其不同中医证型中的作用机制以及与中医辨证分型的关系.方法采用循环酶法和酶动力学比色法分别检测67例寻常型银屑病患者(血热型27例、血毒型18例、血瘀型22例)血中的HCY和UA,并与对照组(61例)行对比分析.结果寻常型银屑病组血HCY、UA水平分别为(14. 13±8. 18) μmol/L和(305. 14±79. 71) μmol/L,高于对照组(9. 31 ±2. 38) μmol/L和(258. 63±73. 10) μmol/L(P<0. 01),及各证型组亦高于对照组(P<0. 05或<0. 01);血毒型和血瘀型血HCY、UA水平高于血热型.结论HCY与UA在寻常型银屑病的过程中可能起一定的作用,可作为寻常型银屑病的中医辨证分型参考依据.%Objective In order to investigate the mechanisms of homocysteine (HCY) and uric acid (UA) in psoriasis vulgaris and their different traditional Chinese medicine (TCM) syndromes and its relationship with different TCM syndrome. Methods Sixty-seven cases of psoriasis vulgaris (27 cases of blood heat type, 18 cases of blood poison type and 22 cases of blood stasis type) blood HCY and UA levels were tested with enzymatic cycling methods and enzyme kinetic colorimetric method and compared with the control group (61 cases). Results The levels of HCY and UA in the patients with psoriasis vulgaris were (14. 13±8. 18) μmol/L and (305. 14±79. 71) μmol/L) respectively, which were higher than those in the control group (9. 31±2. 38) μmol/L and (258. 63±73. 10) μmol/L (P<0. 01) and the same to different TCM syndrome compared with control group (P<0. 05 or <0. 01). Conclusion HCY and UA may play a role in the process of psoriasis vulgaris, which can be used as a reference for the TCM syndrome differentiation of psoriasis vulgaris.
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