Objective To study the correlation between the acute post -stroke depression and lesion position, neurological deficit score ( NIHSS) and event - related potential of P300. Methods Hamilton Depression Rating Scale (HAMD) assessment was adopted to assess the patients of first time stroke. In 78 cases, the stroke patients were divided into groups of post - stroke depression and non-de-pression control group. All the patients were checked by brain CT or MRI within 3 days. The examina-tion of HAMD score, NIHSS score and P300 detection were carried out after 2 weeks. Results There were 32 cases of PSD among the 78 cases with acute stroke, the occurrence rate was 41. 03%. The oc-currence was related to the lesion position and NIHSS score, and the incidence of lesions located in pre-frontal lobe was significantly higher than that in basal ganglia, parietal occipital lobe and cerebellum ( P <0. 01) ; the NIHSS score of PSD group was significantly higher than that of non - PSD group; Com-pared with the non - PSD group, the incubation period of P300 in PSD group was significantly prolonged (P <0. 01) , and the amplitude was reduced significantly (P <0. 01). Conclusion Lesions located in prefrontal temporal lobe are more likely to lead to the PSD, especially in the left frontal lobe, its occur-rence is higher. It is possible for the patients with a serious neurological deficit score to have PSD, and early detection of P300 can improve the identification of PSD, which is beneficial to early intervention of PSD and the recovery of stroke.%目的 研究急性卒中后抑郁(PSD)与病变部位、神经功能缺损评分(NIHSS)及事件相关电位P300的相关性.方法 采用汉密尔顿抑郁量表(HAMD)评定, 将78例首次脑卒中患者分为PSD组和非PSD组.所有患者在发病3 d内进行颅脑CT或MRI检查,2周时进行HAMD、NIHSS评分及P300检测.结果 78例急性脑卒中患者中发生PSD 32例,发生率41.03%,且其发生与病灶部位及NIHSS评分有关,病灶位于额叶的发生率明显高于基底节、顶枕叶及小脑 (P<0.05);PSD组NIHSS评分明显高于非PSD组(P<0.01);与非PSD组相比,PSD组的P300潜伏期显著延长(P<0.01),波幅显著降低(P<0.01).结论 病灶位于额叶的卒中更可能导致 PSD;神经缺损严重的患者患PSD的机率更大,而早期的P300检测可以提高对PSD的识别,有利于临床上对PSD进行早期干预,以利于脑卒中的康复.
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