Acute carbon monoxide ( CO) poisoning refers Lo excessive inhalalion of carbon monoxide in a short Lime. CO poisoning has the higher incidences and morlalilies al present, and is a common disease tha leads Lo the damage of cenlral nervous syslem (CNS). 3% ~ 30% of the palienls with serious poisoning develop an encephalopalhy After a period of "lalenl phase" (3 ~240 days) despile adequate Irealmenl or even when trealed. In this paper, we review the advancement of palhogenesis, pathological features, clinical diagnosis and trealmenl of acule CO poisoning and delayed neuropalhological sequelae (DNS) in order lo provide theorelical basis for basic research and clinical research.%急性一氧化碳中毒是指在短时间内吸入过量一氧化碳(CO)所引起的中毒.它是以中枢神经系统(CNS)损伤为主的全身性疾病,是当今发生率和死亡率最高的中毒.急性CO中毒治疗不及时或者即使经过积极治疗,仍有3%~30%的患者于中毒症状缓解后,经过一段时间的"假愈期"(3~240 d)发生迟发性脑病(DNS).本文重点就急性CO中毒和DNS的发病机制、病理学特点、临床诊断和治疗等的研究进展进行综述,以期为其基础与临床研究提供理论基础.
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