急性心肌梗死和稳定型冠心病患者血清尾加压素Ⅱ和神经激肽 B 的变化

摘要

Objective This study aims to investigate whether there are possible plasma urotensin-II ( U -II ) and neurokinin B ( NKB ) level changes in patients with acute myocardial infarction (AMI) and coronary artery disease (CAD) and to evaluate whether there is any relationship between these changes and the pathogenesis of these diseases.Methods This is a prospective case-control study.Three groups were formed from randomly admitted patients with AMI(n=64), CAD(n=64) and controls ( n =62 ) .Biochemical parameters and U -Ⅱ and NKB levels were measured by biochemistry analyzer.The normality of the data was evaluated using the Kolmogorov-Smirnov test.We compared the three groups with one-way ANOVA and Tukey test ( Kruskal-Wallis test and Mann-Whitney U test) .Results Compared with controls and CAD patients, AMI patients had lower U-Ⅱand NKB levels (P <0.005).In cases of CAD, U -Ⅱ and NKB levels were similar.A positive correlation was found between U-Ⅱand NKB (r=0.720, P=0.000).U-Ⅱ and NKB were poorly correlated with left ventricle ejection fraction but not with C-reactive protein.Conclusion U-Ⅱand NKB levels are lower in patients with AMI in than those with CAD or the control.The decreased U-Ⅱand NKB levels are related to complicated atherosclerotic events.%目的：观察急性心肌梗死（ AMI）和稳定型冠心病（ CAD）患者血清尾加压素Ⅱ（ urotensin－Ⅱ， U－Ⅱ）和神经激肽B（ neurokinin B， NKB）变化情况，评价这些变化与相关疾病发生机制的联系。方法本试验是前瞻性病例对照研究，入院患者随机分成三组：AMI组（ n＝64）、CAD组（n＝64）和对照组（n＝62）。检测相关生化参数、U－Ⅱ及NKB。采用K－S方法评价数据正态性分布，采用单因素方差分析比较三组间数据。结果与对照组和稳定型CAD组比较， AMI组患者血清U－Ⅱ、NKB水平显著降低（P＜0．005），且具有相关性（r＝0．720，P＝0．000）。血清U－Ⅱ、NKB与左心室射血分数（ LVEF）相关性较差，与C－反应蛋白（ CRP）没有相关性。结论 AMI组患者U－Ⅱ和NKB水平降低与动脉粥样硬化具有相关性。