新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹61例疗效观察

摘要

目的观察新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹的疗效及安全性.方法治疗组61例全程口服荆肤止痒颗粒1.5 g,2次/d.第1周每天早、晚外涂新氢松软膏,中午外涂丹皮酚软膏；第2周早、晚外涂丹皮酚软膏,中午外涂新氢松软膏；第3周,早、晚外涂丹皮酚软膏.对照组59例连续外用新氢松软膏,前两周2次/d,第3周改为1次/d.两组均治疗3周判定疗效,治疗过程中观察不良反应.随访4周.结果治疗组痊愈率72.1%,对照组痊愈率54.2%(χ2=4.14,<0.05).治疗组复发率45.5%,对照组复发率71.9%(χ2=5.26,<0.01).两组均未见明显不良反应.结论新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹近、远期疗效均优于单用新氢松软膏,且安全可靠.%　　Objective To study the curative effects and safety quality of the treatment in sequential use of neomycin hydrocortisone ointment and Danpifen ointment combined with Jingfuzhiyang particles for the patients with infantile eczema.Methods 61 cases of the treatment group were treated with Jingfuzhiyang particles 1.5 g,2 times/d.In the first week neomycin hydrocortisone ointment was coated in the morning and the evening per day,at noon Danpifen ointment was coated;in the second week Danpifen ointment was coated in the morning and the evening per day,at noon neomycin hydrocortisone ointment was coated;in the third week Danpifen ointment was coated in the morning and the evening per day.59 cases of the control group were given continuously neomycin hydrocortisone ointment,in the first two week for 2 times/d,in the third week for1 time/d.The two groups were treated for three weeks to determine effects.Adverse reac-tions were observed in the course of treatment,with 4 weeks of follow-up.Results The cure rate of the treatment group was 72.1%, while it was 54.2%in the control group(χ2=4.14,<0.05).The recurrence rate of the treatment group was 45.5%,while the recurrence rate of the control group was 71.9% (χ2=5.26, <0.01).The two groups showed no significant adverse effects.Conclusion The short-term and long-term effects of sequential use of neomycin hydrocortisone ointment and Danpifen ointment combined with Jingfuzhiyang particles to treat infantile eczema are better than the effects of single neomycin hydrocortisone ointment which is safe and reliable.