TGF-β复合BMP盖髓的组织学观察

摘要

目的：用β转化生长因子复合骨形成蛋白(TGF-β/BMP)覆盖狗暴露牙髓，观察TGF-β/BMP的盖髓效果。方法：用活体狗牙作直接盖髓实验，并用组织学方法评价盖髓效果。结果：术后8周，TGF-β/BMP能够诱导牙髓成纤维细胞、内皮细胞增殖并抑制炎症反应，提高牙髓修复能力，有完整的牙本质桥形成。结论：TGF-β/BMP能促进狗牙髓组织修复。%AIM: Observation of the effects of transforming growth factor- β compounded with bone morphogenetic protein (TGF- β/BMP) on the exposed pulp of dogs. METHODS: The teeth of dogs were used for direct pulp capping experiment and the results were evaluated histopathologically. RESULt: Eight weeks postoperatively TGF- β/BMP was able to induce the proliferations of the pulp cells (fibroblasts)and endothelial cell, inhibit the inflammatory reaction of pulp, and possessed the ability to enhance the pulp repairing, complete dentin bridge was induced. CONCLUSION:TGF- β/BMP can promote the regeneration of dog's pulp tissue.