组蛋白去乙酰酶2的结构及其在疾病中的作用

摘要

组蛋白乙酰化作用是目前研究广泛的组蛋白翻译后修饰过程之一,在调节表观遗传过程中发挥重要作用.组蛋白去乙酰酶2作为Ⅰ型组蛋白去乙酰酶中的一员,参与催化调节组蛋白及多种非组蛋白的去乙酰化,调节多种生命过程.本文概述组蛋白去乙酰酶2的基本结构,以及组蛋白去乙酰酶2在各种疾病中发挥的作用,为从事相关研究提供理论依据.%Histone acetylation is one of the most important reactions of post-translational modification of histones, which plays an important role in the regulation of epigenetic processes. Histone deacetylase 2 as a member of type I histone deacetylases,involved in the catalytic regulation of histone and a variety of non-histone deacetylation,regulates a variety of life processes. This paper summarizes the basic structure of histone deacetylase 2 and the role of histone deacetylase 2 in various diseases,and provides a theoretical basis for conducting related studies.