左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床疗效

摘要

Objective To evaluate the safety of levonorgestrel -relea-sing intrauterine system ( LNG-IUS ) in the treatment of endometriosis ( EM) for 5 years.Methods A total of 49 patients with endometriosis were included.The LNG-IUS was inserted into uterine cavity.The ac-ne, facial pigmentation, mammary swelling, the body weight , the body hair and quality of life were scored and compared before and 6, 12, 36, and 60 months after the insertion of the LNG -IUS.Results Compared with prior treatment, the body weight and the scores of the body hair and facial pigmentation showed no marked change at each point of observation time ( P >0.05 ) , and the scores of quality of life and mammary swelling dropped significantly ( P <0.05 ).Six months after insertion, the score of acne had no marked change ( P>0.05 ) , but 12, 36, and 60 months later, it decreased significantly ( P<0.05 ).Conclusion LNG -IUS is safe for long -term treat-ment of endometriosis.%目的：评价左炔诺孕酮宫内缓释系统（ LNG-IUS）治疗子宫内膜异位症（ EM）的长期安全性。方法49例EM患者用LNG-IUS治疗，于治疗前及治疗后6，12，36，60个月，比较患者的痤疮、面部色素沉着、乳房胀痛、体毛、生活质量评分和体重等变化。结果与治疗前相比，49例患者在随访各时间点，观察体毛评分、面部色素沉着评分与体重，差异均无统计学意义（均P＞0.05）；生活质量和乳房胀痛评分均显著好转，差异有统计学意义（均P＜0.05）。与治疗前相比，痤疮评分在治疗6个月后差异无统计学意义（P＞0.05），但治疗12，36，60个月后均明显降低（均P＜0.05）。结论 LNG-IUS是一种可长期治疗EM的安全性较高的治疗方法。