BCL-6P-gp 在初诊弥漫大B 细胞淋巴瘤中的表达及与IPI 指数的相关性研究

摘要

Objective: To investigate the expression of BCL-6 and P-gp in DLBCL and to explore the relationship of BCL-6 and P-gp with the IPI index. Methods: A total of 34 samples were obtained from the pathology department of Fujian provincial hospital. These samples were collected from DLBCL patients treated with more than two therapeutic courses. BCL-6 and P-gp expression, as well as their relationship with the patient prognosis were examined. Results: BCL-6 and P-gp were closely related with the IPI score. BCL-6 was negatively while P-gp was positively correlated with the IPI score. The curative effects of two therapeutic courses had no relation ship with the IPI score but had a negative correlation with BCL-6 and a positive correlation with P-gp. The curative effects of six therapeutic courses had a negative correlation with BCL-6 and positive correlations with the IPI score and P-gp. Conclusion: In DLBCL patients, high BCL-6 expression indicates better prognosis and high P-gp expression indicates poor prognosis.%目的:通过免疫组化方法检测初诊弥漫大B细胞淋巴瘤(DLBCL)患者活检淋巴组织BCL-6、P-gp的表达,探讨初诊DLBCL患者上述指标表达的临床意义以及与IPI指数间的相关性.方法:收集福建省立医院病理科存档的2006年10月～2010年10月,首次确诊DLBCL且接受化疗(CHOP或R-CHOP方案)≥2个疗程患者标本34例(其中27例完成6个疗程化疗),检测BCL-6、P-gp的表达.入选病例根据国际预后指数(IPI)进行评分,将评分结果分别与所检测指标的表达结果进行相关性分析;将患者2、6个疗程化疗疗效分别与IPI评分、BLL-6、P-gp表达进行分析.结果:BCL-6、P-gp高表达与IPI评分密切相关,其中BCL-6高表达与IPI评分呈负相关,P-gp阳性表达与IPI评分呈正相关;2个疗程化疗疗效与IPI评分无相关性,与BCL-6高表达呈负相关,与P-gp呈正相关;6个疗程化疗疗效与BCL-6阳性表达呈负相关,与P-gp呈正相关.结论:在初诊DLBCL患者中,BCL-6高表达与良好预后相关,P-gp高表达则提示预后不良.