胃癌组织中SNCG和CXCR4 mRNA的表达及临床意义

摘要

Objective:To detect expression of SNCG and CXCR4 mRNA in gastric adenocarcinoma and evaluate its function in carcinogenesis, progression, infiltration, and metastasis, as well as the correlation of these proteins. Methods:The expression of SNCG and CXCR4 mRNAs was detected using reverse transcription-polymerase chain reaction in gastric adenocarcinoma and normal gastric mucosa. Results:The expression of SNCG and CXCR4 mRNAs was obviously higher in gastric adenocarcinoma than in normal gastric mucosa (P<0.01). The expression of SNCG mRNA was closely correlated with tumor infiltration depth (P<0.05) and lymph node metas-tasis (P<0.01). The expression of CXCR4 mRNA closely correlated with lymph node metastasis (P<0.01). The expression of SNCG and CXCR4 mRNAs positively correlated in 29 cases of gastric adenocarcinoma (r=0.346, P<0.05). Conclusion:SNCG and CXCR4 may be overexpressed in tumor tissue and may have important functions in tumorigenesis, progression, infiltration, and metastasis of gastric adenocarcinoma.%目的：研究SNCG和CXCR4在胃癌和正常胃黏膜组织中的表达，探讨其在胃癌发生、发展、浸润转移中的作用。方法：应用RT-PCR法检测不同组织中SNCG和CXCR4 mRNA的表达情况。结果：SNCG和CXCR4 mRNA在胃癌组织中的表达量明显高于正常胃黏膜组织（P<0.01）；胃癌组织中SNCG mRNA的表达量与癌组织的浸润深度和淋巴结转移有关（P<0.05，P<0.01），CXCR4 mRNA的表达量与淋巴结转移有关（P<0.01）；胃癌组织中SNCG mRNA与CXCR4 mRNA的表达量呈正相关（r=0.346，P<0.05）。结论：SNCG和CXCR4在胃癌组织中高表达，可能与胃癌的发生、发展、浸润、转移密切相关。