轴突导向蛋白4D在肿瘤进展中的作用

摘要

Semaphorin 4D (SEMA4D), also known as CD100, is a protein that belongs to class IV semaphorin. Its physiologic role in the nervous system has been extensively explored. However, the roles of SEMA4D have extended beyond the traditionally studied territories. Collective data proved that SEMA4D has an important role in the regulation of immune system, angiogenesis, and tumorigenesis, among others. Specifically, SEMA4D enhanced the angiogenesis in malignant diseases. This review summarized the latest progression in the research on SEMA4D, including the structure, receptors, mechanism, and biological functions in tumor angiogenesis and progression.%轴突导向蛋白4D（SEMAPHORIN4D，SEMA4D）又称CD100，是轴突导向蛋白Ⅳ亚族（SEMAsⅣ）的重要成员之一，其最初作为影响神经发育的轴突导向分子被发现。近来越来越多的研究表明，SEMA4D在免疫调节、血管发生及肿瘤生长转移等方面也有重要的生物学功能，尤其作为新的促血管生成分子，SEMA4D的相关研究引起广泛关注。本文旨在对SEMA4D的结构、受体特点、促血管生成及肿瘤侵袭转移等方面的最新研究进展进行综述。