时钟基因PER在肿瘤中的研究进展

摘要

Circadian clock governs 24-hour rhythms in body temperature, blood pressure, circulating hormones, metabolism, and oth-er physiological parameters in humans and most mammals. The circadian clock is regulated by circadian clock genes. For instance, peri-od (PER) is a core circadian clock gene. Human PER includes PER1, PER2, and PER3, which play a role in cancer suppression. Abnormal PER expression not only causes cancer but also changes cellular sensitivity to radiation and chemotherapeutic drugs. Thus, this theory has provided a new direction for cancer radiotherapy and chemotherapy. This paper presents the research progress on PER in tumors.%昼夜节律钟控制着人类及大多数哺乳动物每天的体温、血压、激素、代谢等节律，这是由于昼夜节律基因调控的结果。PER（period）基因是核心昼夜节律基因之一，现已确认人类的PER基因包括PER1、PER2和PER3，均是抑癌基因。PER基因的表达异常不仅能促进肿瘤的发生，还能改变细胞对放射线和化疗药物的敏感性，为肿瘤患者的放疗和化疗提供新的治疗方向。本文在将对昼夜节律钟基因PER在肿瘤中的研究进展进行综述。