25岁以下极年轻乳腺癌研究进展

摘要

年轻乳腺癌较老年乳腺癌侵袭性更强,预后更差,但年龄界限并不清晰,年龄作为预后因素是否为连续性变量仍需论证.其中年轻妊娠相关性乳腺癌患者具有特殊的临床及预后特征.本文将25岁及以下乳腺癌定义为极年轻乳腺癌(very young breast cancer,VYBC),对其遗传学因素、临床病理特征、预后、治疗以及妊娠相关性乳腺癌等进行综述,以期为更佳治疗选择提供帮助.%Breast cancer in younger patients exhibits stronger invasiveness and poorer outcomes compared with that in elders. Cut-off for young age remains unclear, and its basis as prognostic factor representing a continuous variable requires further investigation. Preg-nancy-associated breast cancer in young patients also possesses unique biological features. In this review, we define breast cancer di-agnosed in patients below 25 years old as very young breast cancer and summarize recent studies based on genetic factors, clinicopa-thology, prognostic characteristics, and pregnancy-associated breast cancer to assist in management of very young breast cancer pa-tients.