30岁以下年轻乳腺癌病理类型、临床分析及预后

摘要

Objective To analyze the pathologic type,clinical analysis and prognosis of young breast cancer below 30 years old. Methods 64 breast cancer patients below 30 years old from June 2005 to June 2010 were selected,clinical pathologic features and the immunohistochemical expression of ER,PR,C-erbB-2 were analyzed,clinical significance was investigated; all the patients were followed-up for 2 years. Results 53 cases of invasive ductal carcinoma were found,which accounted for 82.8%; 5 cases of ductal carcinoma were found,which accounted for 7.81%; 2 cases of mucinous adenocarcinoma were found,which accounted for 3.12%; 2 cases of apocrine carcinoma were found,which accounted for 3.12%; 1 case of intraductal papillary carcinoma was found,which accounted for 1.56%; 1 case of invasive micropapillary carcinoma was found,which accounted for 1.56%. No relation was found among the Patients' age and ER,PR,C-erbB-2,lymph node metastasis (P > 0.05). Negative correlation was found between ER and height (P < 0.05). Positive relation was found among the number of lymph nodes metastasis and ER,C-erbB-2 (P < 0.05),but negative relation was found between the number of lymph nodes metastasis with weight (P < 0.05). Positive relation was found among ER,PR and C-erbB-2 (P < 0.05). 64 patients were found survived,4 cases were found relapsed and vital organ metastasized after a 2-year follow-up visit. Conclusion Young breast cancer patients mostly are invasive ductal carcinoma. C-erbB-2,ER,PR expression have relationship with prognosis,which can estimate the prognosis of breast cancer and formulate for the clinical comprehensive treatment of breast cancer.%目的 分析30岁以下年轻乳腺癌病理类型、临床分析及预后.方法选择2005年6月～2010年6月30岁以下经病理确诊并采用常规免疫组化法检测的女性乳腺癌患者64例进行分析,免疫组化法检测ER(雌激素受体)、PR(孕激素受体)、C-erbB-2(表皮生长因子受体2)表达情况,探讨其临床意义,并进行2年随访.结果浸润性导管癌53例,占82.8%；导管内癌5例,占7.81%；黏液腺癌2例,占3.12%；大汗腺癌2例,占3.12%；导管内乳头状癌1例,占1.56%；浸润性微乳头状癌1例,占1.56%.患者发病年龄与ER、PR、C-erbB-2、淋巴结转移无相关性(P > 0.05)；ER与身高有负相关性(P < 0.05)；淋巴结转移数与ER及C-erbB-2正相关,与体重负相关(均P < 0.05)；ER、PR、C-erbB-2互为正相关性(均P < 0.05).随访2年,64例患者均存活,4例复发及重要器官发生转移.结论年轻乳腺癌以浸润性导管癌为主,C-erbB-2、ER、PR表达与年轻乳腺癌的预后相关,是判断乳腺癌预后的重要指标,可以为临床制定乳腺癌的综合治疗方案提供重要依据.