小细胞肺癌合并抗利尿激素分泌异常综合征的研究进展

摘要

Many malignant tumors, most commonly small cell lung cancer, merge with syndrome of inappropriate secretion of antidi-uretic hormone (SIADH). SIADH is caused by the neuroendocrine function of tumor cells or is a side effect of chemotherapeutics. As a chemotherapeutic side effect, SIADH presents as hyponatremia. Therapy for SIADH includes both treatment for primary diseases and hyponatremia. Given that SIADH-induced hyponatremia aggravates the prognosis and shortens the survival time of patients with malig-nant tumors, SIADH is an independent risk factor for prognosis. Therefore, the early diagnosis, monitoring, and treatment of SIADH will improve the prognosis of patients with malignant tumors.%恶性肿瘤可能合并抗利尿激素分泌异常综合征,其中以小细胞肺癌(small cell lung cancer,SCLC)最为多见.抗利尿激素分泌异常综合征(syndrome of inappropriate secretion of antidiuretic hormone,SIADH)主要是由于肿瘤细胞的神经内分泌功能或某些化疗药物的作用所致,具体表现为低钠血症,治疗方案主要包括针对原发病的治疗及针对低钠血症的治疗.继发于SIADH的低钠血症会影响患者预后,缩短生存时间,是肿瘤不良预后的独立危险因素.因此,对肿瘤患者SIADH的早期诊断、监测、治疗可改善患者的预后.