抗苗勒管激素对多囊卵巢综合征卵巢反应的预测作用

摘要

目的：探讨抗苗勒管激素（AM H）对多囊卵巢综合征（PCOS）超排卵的预测价值。方法：选择2011年1月—2014年12月在复旦大学附属中山医院接受体外受精联合胚胎移植技术（IVF）助孕的PCOS患者80例，另选择同期因输卵管因素接受IVF的患者30例作为对照组。采用酶联免疫吸附法（ELISA）检测血清AM H水平，微粒子化学发光免疫法测定卵泡刺激素（FSH）、黄体生成素（LH）及雌二醇（E2）水平。结果：与对照组相比，PCOS组患者血清 AMH[（30．35±9．22） pmol／L 比（14．92±4．20） pmol／L]和LH[（10．36±3．16） IU／L 比（5．73±2．36） IU／L]均显著升高，差异有统计学意义（P＜0．05）。正常获卵组AMH水平高于低获卵组（P＜0．05），高获卵组高于正常获卵组（P＜0．01）；PCOS患者血清AMH水平与获卵数正相关。结论：PCOS血清AM H水平对卵巢超排卵反应有较好的预测价值。%Objective:To explore the predictive value of anti‐Müllerian hormone (AMH) in in vitro fertilization (IVF) procedure of women with polycystic ovary syndrome (PCOS) .Methods:A total of 80 patients with PCOS who received IVF treatment were selected during January 2011 to December 2014 in Zhongshan Hospital ,Fudan University .Enzyme‐linked immunoassay (ELISA) was applied to detect the serum levels of AM H ,and microparticle chemiluminescent immunoassay was used to detect the levels of follicle stimulating hormone (FSH) ,luteinizing hormone (LH) and estradiol (E2 ) .Results:Serum AMH([30 .35 ± 9 .22] pmol/L vs .[14 .92 ± 4 .20] pmol/L)and LH([10 .36 ± 3 .16] IU/L vs .[5 .73 ± 2 .36] IU/L) in patients of PCOS groups were significantly higher than those in control group (P< 0 .05) .Compared with the low oocytes group ,the AMH in the normal response group was significantly increased (P< 0 .05) .Compared with the normal response group ,the AM H in the high response group was significantly increased (P<0 .01) .There was a positive relationship between serum AM H and occytes obtained .Conclusions:Serum AM H level has a predictive value in the ovarian response in patients w ith PCOS .