上海地区高危人群及体检人群HPV亚型感染分布调查

摘要

Objective:To clarify the subtype infection status,distribution characteristics of human papilloma virus (HPV),and its correlation with cervical lesions in different groups in Shanghai.Methods:2126 female patients of the gynecology clinic and routine physical examination were detected for HPV genotypes,comparing the distribution of HPV infection and subtypes.Results:HPV overall infection rate,high-risk HPV (HR-HPV)infection rate,single and multiple infection rate in high-risk group,were significantly higher than physical group(P<0.05).HR-HPV,low-risk HPV (LR-HPV)distribution of the two groups were slightly different.HPV infection rate in high-risk group showed bimodal age distribution,with a peak at the<30 age group and the second one at >60 age group,while the <30 age group showed the highest infection rate in physical group.HPV subtypes in each disease group were slightly different.HPV1 6 subtype detection rate increased with the malignancy in cervical lesions,(P<0.05 ).Conclusions:The distribution of HPV infection and pathogenic subtypes of Shanghai was region specific.HPV infection status were different between two risk groups.The latent infection rate of HPV is high in Shanghai population.HPV1 6 subtype has the highest carcinogenic potential in Shanghai.%目的：探讨上海地区不同人群中人乳头状瘤病毒（HPV）亚型感染状况，分布特点，及其与宫颈病变的相关性。方法：选取本院妇科门诊及常规体检，接受HPV检测的2126例女性患者，比较HPV感染及亚型分布特点。结果：高危组HPV总感染率、高危型HPV（HR-HPV）感染率、单一及多重感染率均显著高于体检组（均P＜0．05）。两组HR-HPV、低危型HPV（LR-HPV）分布略有差异。高危组HPV感染年龄呈双峰分布，＜30和＞60岁年龄组感染率最高，而体检组感染率以＜30岁年龄组最高。各疾病组HPV亚型分布略有差异，随着宫颈病变程度增加，HPV16亚型检出率逐渐上升（P＜0．05）。结论：上海地区HPV感染及致病亚型分布存在地区特异性，地区内不同风险组HPV感染状况亦有差异，人群HPV潜伏感染率高，HPV16亚型在本地区具有高致癌性。