帕瑞昔布钠对气管插管全麻患者术后声音嘶哑与咽喉痛的影响

摘要

目的:评价帕瑞昔布钠对气管插管全麻手术患者术后声音嘶哑与咽喉痛的影响.方法:择期气管插管全麻手术患者120例,美国麻醉医师协会(ASA)分级Ⅰ～Ⅱ级,年龄20～60岁,体质量45～80 kg.采用随机数字表法,将患者随机分为帕瑞昔布钠组和对照组.帕瑞昔布钠组在麻醉诱导过程中给予帕瑞昔布钠40 mg;对照组在麻醉诱导过程中给予等容量0.9％氯化钠液.两组均静脉注射咪达唑仑、舒芬太尼、丙泊酚和罗库溴铵诱导麻醉,气管插管后行机械通气,分别于术后1、2、6、8h评估患者术后声音嘶哑与咽喉痛情况.结果:与对照组相比,帕瑞昔布钠组术后1、2、6h声音嘶哑发生率明显降低(P＜0.05),声音嘶哑程度明显降低(P＜0.05);术后8h,两组声音嘶哑发生率及声音嘶哑程度差异无统计学意义.与对照组相比,帕瑞昔布钠组术后1、2、6、8h咽喉痛发生率及程度均明显降低(P＜0.05).结论:帕瑞昔布钠可有效降低气管插管全麻患者术后短期声音嘶哑与咽喉痛的发生率及程度.%Objective:To evaluate the effect of parecoxib sodium on the incidence and severity of postoperative hoarseness and sore throat in general anaesthesia patients.Methods:One hundred and twenty patients,with ASA physical status Ⅰ or Ⅱ,aged 20-60 yr,weighing 45-80 kg,undergoing general anesthesia were randomly allocated to parecoxib sodium group or normal saline group equally.In parecoxib sodium group,parecoxib sodium 40 mg was infused during induction of anesthesia,while the equal volume of 0.9％ normal saline was given instead in normal saline group.Anesthesia was intravenously induced with midazolam (0.05 mg/kg),sufentanyl (0.2-0.3 μg/kg),rocuronium (0.7 mg/kg) and propofol (2.0 mg/kg) and mechanical ventilation was applied after tracheal intubation in both groups.The incidence and severity of postoperative hoarseness and sore throat were evaluated 1,2,6,and 8 h after surgery.Results:Compared with normal saline group,the incidence and severity of postoperative hoarseness were significantly reduced by parecoxib sodium at 1,2,and 6 h time points in parecoxib sodium group (P＜0.05),except for time point of 8 h.The incidence and severity of postoperative sore throat was significantly reduced at 1,2,6,and 8 h time points in parecoxib sodium group,compared with normal saline group (P＜0.05).Conclusions:Parecoxib sodium provides efficacy in reducing the incidence and severity of postoperative hoarseness and sore throat in short term after surgery.