Objective To study the change of bone mineral density ( BMD) in postmenopausal osteoporosis after alendronate treatment .Methods Patient selected from the Geriatric Departement of Shanxi Provincial People's Hospital with simple randomized method , the research object will be divided into experimental group and control group.The whole treatment lasted for 12 months,before and during the treatment ,at end of 6 and 12 months of alendr-onate did curative effect evaluation .Results Sixty cases were analyzed ( calcium carbonate group 30 casesand alen-dronate sodium group 30 cases).After treatment,at the end of 6 and 12 months:hip bone mineral density of alendr-onate group was significantly higher than that of calcium carbonate group ,and the results have significant difference (P<0.05).Osteocalcin in alendronate group reduced significantly than that in calcium carbonate group (P<0.05). Type I collagen amino terminal peptide ( NTX/Cr) in alendronate group also reduced significantly than that in calci-um carbonate group (P<0.01).Fracture rate of alendronate group was 3.33%,while calcium carbonate group was 16.67%.Two groups were dramatically different ,P<0.001.Conclusion Compared with calcium carbonate ,alendr-onate could reduce bone conversion ,increase the bone mineral density ,and reduce the incidence of fracture in postm-enopausal osteoporosis .%目的：探讨阿仑膦酸钠增加绝经后妇女骨密度，降低骨折的疗效。方法陕西省人民医院老年病门诊及住院患者，用简单随机化方法分为研究组和对照组。研究疗程为12个月，在治疗前、6个月末和12个月末对阿仑膦酸钠的疗效进行评估。结果本研究共入组60例（碳酸钙组：30例、阿仑膦酸钠组：30例），在6个月末和12个月末：髋骨的骨密度阿仑膦酸钠组较碳酸钙组明显增高，差异有统计学意义（ P＜0．05）。骨钙素测定阿仑膦酸钠组较碳酸钙组明显降低，差异有统计学意义（ P＜0．05）。尿Ⅰ型胶原氨基末端肽/肌酐（NTX/Cr）阿仑膦酸钠组较碳酸钙组明显降低（P＜0．01）。再发骨折率阿仑膦酸钠组（3．33％）较碳酸钙组（16．67％）明显下降（P＜0．01）。结论与碳酸钙对比，阿仑膦酸钠降低骨转换，增加绝经后骨质疏松症患者的骨密度，减少骨折发生率。
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