黄芪联合川芎嗪交替穴位注射辅助治疗慢性肾衰竭非透析患者的临床观察

摘要

目的：观察黄芪联合川芎嗪交替穴位注射对慢性肾衰竭（CRF）非透析患者脾肾两虚、浊瘀内蕴者的临床疗效及对微炎症状态的影响，并探讨此疗法是否可作为辅助治疗 CRF 的有效方法之一加以推广。方法将符合纳入标准的80例患者采用随机数字表法平均分为治疗组和对照组，对照组仅予一般治疗，治疗组在对照组的基础上加用黄芪联合川芎嗪交替穴位注射，15 d 为1疗程，治疗周期为2个疗程，观察患者治疗前后血肌酐（Scr）、尿素（Bun）、尿酸（UA）、血红蛋白（Hb）、红细胞比容（Hct）及血清 C 反应蛋白（CRP）水平的变化。结果与同组治疗前相比，治疗组治疗后 Scr、BUN 及 CRP 显著下降（P ＜0．01），UA 有所下降（P ＜0．05），Hb、Hct 水平有所升高（P ＜0．05），对照组治疗后 Scr、BUN、UA 及 CRP 有所下降（P ＜0．05），Hb、Hct 水平有所升高（P ＜0．05）。治疗后治疗组 Scr、BUN 及 CRP 的效果优于对照组（P ＜0．05）。结论黄芪联合川芎嗪交替穴位注射辅助治疗可改善患者肾功能及微炎症状态，可为 CRF 的治疗提供一种有效方法。%Objective To observe the clinical effects and influence of astragalus membranaceus combined li-gustrazine alternating point injection on slight inflammatory state in-into dialysis patients with chronic renal failure be-longed to deficiency of spleen and kidney and turbidity stasis intrinsic.Methods 80 cases included in the standard were randomly divided into treatment group and control group.The control group were given general treatment,and the treatment group were given treatment of astragalus membranaceus combined ligustrazine alternating point injec-tion on the basic of general treatment .All cases were under treatment for two courses,fifteen days was one treatment course.To observe the change of serum creatinine (Scr),blood urea (Bun),uric acid (UA),hemoglobin (Hb), red blood cells deposited (Hct),and serum C-reactive protein (CRP)in all cases before and after treatment.Re-sults Compared with pretreatment,the levels of Scr,BUN and CRP in the treatment group decreased significantly (P <0.01);UA was also decreased (P <0.05);but Hb and Hct increased (P <0.05)after the treatment.The lev-els of Scr,BUN,UA and CRP in the control group decreased (P <0.05);Hb and Hc were increased (P <0.05).Af-ter treatment,the improvements of Scr,BUN and CRP in the treatment group were better than those in the control group (P <0.05).Conclusion Astragalus membranaceus combined ligustrazine alternating point injection ,which improve renal function and slight inflammatory state in patients with chronic renal failure,would be an effective meth-od for the treatment of chronic renal failure.